Endoscopic Considerations in Gastroesophageal Reflux Disease

  • W. Scott Melvin
  • Jeffrey L. Eakin


Gastroesophageal reflux disease affects approximately 50 million Americans and some studies estimate the prevalence approaches 20 % of the population in many Western countries. Approximately 50 % of the U.S. population experiences gastroesophageal reflux disease astroesophageal reflux disease-related symptoms once a month, and one in ten Americans experience symptoms of heartburn and bloating every day. This tremendously prevalent condition has had and will continue to have a significant economic impact on the Unites States and other developed Western countries. In view of that, numerous countries expend a considerable amount of resources on direct and indirect costs attributable to the prevention and treatment of reflux disease. Gastroesophageal reflux disease has a substantial impact on clinical and financial welfare since patients suffering from this disorder generally report a diminished health-related quality of life (HRQL), reduced work productivity, and depressed psychological health.


Lower Esophageal Sphincter Distal Esophagus Lower Esophageal Sphincter Pressure Esophageal Acid Exposure Radiofrequency Energy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Heidelbaugh JJ, Goldberg KL, Inadomi JM. Overutilization of proton pump inhibitors: a review of cost-effectiveness and risk [corrected]. Am J Gastroenterol. 2009;104 Suppl 2:S27–32.PubMedCrossRefGoogle Scholar
  2. 2.
    Revicki DA, Wood M, Maton PN, Sorenson S. The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med. 1998;104:252–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Read RC. The contribution of Allison and Nissen to the evolution of hiatus herniorrhaphy. Hernia. 2001;5:200–3.PubMedCrossRefGoogle Scholar
  4. 4.
    Dallemagne B, Weerts JM, Jehaes C, Markiewicz S, Lombard R. Laparoscopic Nissen fundoplication: preliminary report. Surg Laparosc Endosc. 1991;1(3):138–43.PubMedGoogle Scholar
  5. 5.
    Donahue PE, Carvalho P, Yoshida J, et al. Endoscopic sclerosis of the cardia affects gastroesophageal reflux. Surg Endosc. 1989;3(1):11–2.PubMedCrossRefGoogle Scholar
  6. 6.
    Dent J, Dodds WJ, Friedman RH. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest. 1980;65:256–67.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Deviere J, Pastorelli A, Louis H, de Maertelaer V, Lehman G, Cicala M, et al. Endoscopic implantation of a biopolymer in the lower esophageal sphincter for gastroesophageal reflux: a pilot study. Gastrointest Endosc. 2002;55(3):335–41.PubMedCrossRefGoogle Scholar
  8. 8.
    Johnson DA, Ganz R, Aisenberg J, Cohen LB, Deviere J, Foley TR, et al. Endoscopic, deep mural implantation of Enteryx for the treatment of GERD: 6-month follow-up of a multicenter trial. Am J Gastroenterol. 2003;98(92):250–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Fockens P, Bruno MJ, Gabbrielli A, Odegaard S, Hatlebakk J, Allescher HD, et al. Endoscopic augmentation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease: multicenter study of the gatekeeper reflux repair system. Endoscopy. 2004;36(8):682–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Utley DS, Kim M, Vierra MA, Triadafilopoulos G. Augmentation of lower esophageal sphincter pressure and gastric yield pressure after radiofrequency energy delivery to the gastroesophageal junction: a porcine model. Gastrointest Endosc. 2000;52(1):81–6.PubMedCrossRefGoogle Scholar
  11. 11.
    Richards WO, Houston HL, Torquati A, Khaitan L, Holzman MD, Sharp KW. Paradigm shift in the management of gastroesophageal reflux disease. Ann Surg. 2003;237(5):638–49.PubMedPubMedCentralGoogle Scholar
  12. 12.
    Richards WO, Scholz S, Khaitan L, Sharp KW. Holzman Initial experience with the stretta procedure for the treatment of gastroesophageal reflux disease. J Laparoendosc Adv Surg Tech A. 2001;11(5):267–73.PubMedCrossRefGoogle Scholar
  13. 13.
    Perry KA, Banerjee A, Melvin WS. Radiofrequency energy delivery to the lower esophageal sphincter reduces esophageal acid exposure and improves GERD symptoms: a systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 2012;22(4):283–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Renteln D, Schiefke I, Fuchs K, et al. Endoscopic full-thickness plication for the treatment of gastroesophageal reflux disease using multiple Plicator implants: 12-month multicenter study results. Surg Endosc. 2009;23(8):1866–75.CrossRefGoogle Scholar
  15. 15.
    Filipi CJ, Lehman GA, Rothstein RI, et al. Transoral, flexible endoscopic suturing for treatment of GERD: a multicenter trial. Gastrointest Endosc. 2001;53(4):416–22.PubMedCrossRefGoogle Scholar
  16. 16.
    Pleskow D, Rothstein R, Lo S, et al. Endoscopic full-thickness plication for the treatment of GERD: 12-month follow-up for the North American open-label trial. Gastrointest Endosc. 2005;61(6):643–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Pleskow D, Rothstein R, Kozarek R, et al. Endoscopic full-thickness plication for the treatment of GERD: five-year long-term multicenter results. Surg Endosc. 2008;22(2):326–32.PubMedCrossRefGoogle Scholar
  18. 18.
    Mahmood Z, McMahon B, Arfin Q, et al. Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up. Gut. 2003;52(1):34.PubMedCrossRefPubMedCentralGoogle Scholar
  19. 19.
    Schwartz MP, Wellink H, Gooszen HG, Conchillo JM, Samsom M, Smout AJ. Endoscopic gastroplication for the treatment of gastrooesophageal reflux disease: a randomised, sham-controlled trial. Gut. 2007;56:20–8.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Petersen RP, Filippa L, Wassenaar EB, Martin AV, Tatum R, Oelschlager BK. Comprehensive evaluation of endoscopic fundoplication using the EsophyXTM device. Surg Endosc. 2012;26:1021–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Cadière GB, Rajan A, Rqibate M, Germay O, Dapri G, Himpens J, et al. Endoluminal fundoplication (ELF)—evolution of EsophyXTM, a new surgical device for transoral surgery. Minim Invasive Ther Allied Technol. 2006;15:348–55.PubMedCrossRefGoogle Scholar
  22. 22.
    Cadière GB, Rajan A, Germay O, Himpens J. Endoluminal fundoplication by a transoral device for the treatment of GERD: a feasibility study. Surg Endosc. 2008;22:333–42.PubMedCrossRefGoogle Scholar
  23. 23.
    Cadière G-B, Van Sante N, Graves JE, Gawlicka AK, Rajan A. Two-year results of a feasibility study on antireflux transoral incisionless fundoplication using EsophyX. Surg Endosc. 2009;23(5):957–64.PubMedCrossRefGoogle Scholar
  24. 24.
    Demyttenaere SV, Bergman S, Pham T, Anderson J, Dettorre R, Melvin WS, et al. Transoral incisionless fundoplication for gastroesophageal reflux disease in an unselected patient population. Surg Endosc. 2010;24(4):854–8.PubMedCrossRefGoogle Scholar
  25. 25.
    Wendling MR MW, Perry K. Impact of transoral incisionless fundoplication on subjective and objective GERD indices: a meta-analysis of the published literature. J Soc Am Gastrointest Endosc Surg (Unpublished data).Google Scholar
  26. 26.
    Bonavina L, DeMeester T, Fockens P, Dunn D, Saino G, Bona D, et al. Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: one and two year results. Ann Surg. 2010;252(5):857–62.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of General SurgeryThe Ohio State University HospitalColumbusUSA
  2. 2.Department of General Surgery Center for Minimally Invasive SurgeryThe Ohio State University Medical CenterColumbusUSA

Personalised recommendations