The Transgenerational Effects of Parental Exposure to Mutagens in Mammals
The review describes the transgenerational effects of parental exposure to ionizing radiation, chemical mutagens and anticancer drugs. The results of some recent animal studies showing elevated mutation rates in the non-exposed offspring of irradiated parents are presented and discussed. The possible mechanisms and implications of transgenerational instability are also discussed.
KeywordsElectrophoresis Adduct Cyclophosphamide Guanine Mitomycin
This work was supported by grants from the European Commission (NOTE, Contract Number 036465), Cancer Research UK (Contract Number C23612/A9483 and C23912/A12262), the Wellcome Trust (Contract Number 091106/Z/10/Z), and the EMF Biological Research Trust (Contract Number BRT 11/42).
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