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In-Vivo NIRS and Muscle Oxidative Metabolism

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Book cover Application of Near Infrared Spectroscopy in Biomedicine

Part of the book series: Handbook of Modern Biophysics ((HBBT,volume 4))

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Abstract

Muscle oxidative metabolism has often been examined by traditional analytical biochemistry based on obtaining biopsy samples and invasive intravascular catheterization on muscle at rest and during exercise. Myoglobin O2 saturation and reduced nicotinamide adenine dinucleotide (NADH) redox state also can be detected using freeze-clamped tissue. NIRS has been utilized as a noninvasive approach to evaluate skeletal muscle O2 dynamics and energetics during exercise. Applying the NIRS technology requires attention to the validity and calibration of the measurements as well as to the underlying basis for biochemical, physiological, pathophysiological interpretation.

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Acknowledgments

I would like to acknowledge funding support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Authors and Affiliations

  1. Department of Sport and Health Science, Ritsumeikan University, 1 Nojihigashi, Kusatsu, Shiga, Japan

    Takafumi Hamaoka M.D., Ph.D.

Authors
  1. Takafumi Hamaoka M.D., Ph.D.
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Correspondence to Takafumi Hamaoka M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. BIOCHEMISTRY & MOLECULAR MEDICINE, University of California Davis BIOCHEMISTRY & MOLECULAR MEDICINE, Davis, California, USA

    Thomas Jue

  2. Kanazawa University, Kanazawa, Japan

    Kazumi Masuda

Appendices

Problems

  1. 5.1

    How would you quantify muscle NIR signals?

  2. 5.2

    List the various muscle NIR indicators. Which indicator reflects muscle oxidative function? How?

Further Reading

Ferrari M, Muthalib M, Quaresima V (2011) The use of near-infrared spectroscopy in understanding skeletal muscle physiology: recent developments. Philos Trans A Math Phys Eng Sci 369:4577–4590.

Hamaoka T, McCully K, Quaresima V, Yamamoto K, Chance B (2007) Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans. J Biomed Opt 12(6):62105–62120.

Hamaoka T, McCully K, Quaresima V, Yamamoto K, Chance B (2011) The use of muscle near-infrared spectroscopy in sport, health, and medical sciences: recent developments. Philos Trans A Math Phys Eng Sci 369:4591–4604.

Yamamoto K, Niwayama M, Lin L, Shiga T, Kudo N, Takahashi M (1998) Accurate NIRS measurement of muscle oxygenation by correcting the influence of a subcutaneous fat layer. Proc SPIE 3194:166–173.

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Hamaoka, T. (2013). In-Vivo NIRS and Muscle Oxidative Metabolism. In: Jue, T., Masuda, K. (eds) Application of Near Infrared Spectroscopy in Biomedicine. Handbook of Modern Biophysics, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6252-1_5

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