Non-canonical Roles for the Hippo Pathway

Varelas, Xaralabos

doi:10.1007/978-1-4614-6220-0_17

Non-canonical Roles for the Hippo Pathway

Xaralabos Varelas Ph.D.³

Chapter
First Online: 01 January 2013

1915 Accesses
1 Citations

Abstract

The Hippo pathway is a conserved signaling pathway that mediates tissue and organ growth, and is commonly deregulated in diseases such as cancer. A series of phosphorylation events and protein interactions propagate Hippo pathway signaling and culminate in the modulation of the transcriptional regulators TAZ and YAP. The majority of effort to date has focused on identifying new players in the pathway and understanding the transcriptional processes regulated by TAZ and YAP. However, it has become clear that the ramifications of Hippo pathway activity extend well beyond that of transcriptional regulation. Hippo pathway components have been implicated in a wide-range of processes that range from the organization of cell polarity to the fine-tuning of morphogen signaling. This chapter highlights some of the non-canonical roles for the Hippo pathway and discusses how these functions influence organogenesis and disease.

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Acknowledgements

Work in XV’s laboratory is supported in part by Research Grant No. 5-FY11-578 from the March of Dimes Foundation and by funds from the Concern Cancer Foundation.

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Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Silvio Conte Building, K-620, Boston, MA, 02118, USA
Xaralabos Varelas Ph.D.

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Xaralabos Varelas Ph.D.
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Correspondence to Xaralabos Varelas Ph.D. .

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, Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel
Moshe Oren
, Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel
Yael Aylon

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Varelas, X. (2013). Non-canonical Roles for the Hippo Pathway. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_17

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DOI: https://doi.org/10.1007/978-1-4614-6220-0_17
Published: 05 February 2013
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6219-4
Online ISBN: 978-1-4614-6220-0
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