Hippo Signaling and Stem Cells
The normal growth and development of an organ is dependent on the precise balance of stem cell self-renewal and differentiation. Slightest aberrations in signals stem cells receive can cause growth abnormalities and cancer. Emerging data suggest that the highly conserved Hippo signaling pathway can directly regulate stem cell proliferation and maintenance to control organ size. Furthermore, deregulation of the pathway promotes cancer stem cell-like properties and leads to tumor formation. Together, these findings implicate that the Hippo pathway modulates the dynamic activity of stem cells in tissue repair, regeneration, and development. Here, we summarize the latest findings that establish the role of Hippo pathway in stem cell biology.
KeywordsStem cell Cancer Hippo pathway Organ size Cancer stem cell
We apologize to those investigators whose work we could not cite due to limited space. We thank Annie M. Tremblay, Evan Barry, and Morvarid Mohseni for providing feedback and proofreading this manuscript. Fernando D. Camargo is a Pew Scholar and is supported by grants from the National Institutes of Health, the Stand Up to Cancer Foundation and the Department of Defense.
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