Roles of Hippo Signaling During Mouse Embryogenesis
Embryos undergo dynamic morphological changes during embryogenesis, and elaborate the basic body plan of adults from a single fertilized egg. The Hippo signaling pathway, originally identified as a tumor suppressor signaling pathway in Drosophila, is conserved in mice and controls intercellular communication by cell–cell contacts. Recent studies of mouse mutants reveal the roles of Hippo pathway components in the various stages of embryogenesis. Hippo signaling not only regulates cell proliferation and apoptosis but also controls cell fate specification. In this review, I summarize the roles of Hippo signaling during early embryogenesis and discuss the conservation and divergence of the roles and pathways in flies and mice depending upon the developmental stages.
KeywordsMouse development Preimplantation development Embryogenesis Trophectoderm Notochord Cell proliferation
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