Hippo and Mouse Models for Cancer
Among the many signaling pathways related to cancer initiation and progression, the Hippo pathway has emerged recently as a mediator of tumor suppression that is evolutionarily conserved from flies to humans and plays a key role in normal organ development. Genetic engineering of the Hippo pathway in mice has provided important insights into its tumor suppression function. These mouse models have also revealed both canonical and noncanonical modes of action for pathway components in tumor suppression. In this chapter, we first discuss genetic and epigenetic changes identified for Hippo pathway components in human cancers. We then describe established mouse models of cancer related to the Hippo pathway, dividing them into those in which the canonical pathway functions through inhibition of the transcriptional co-activator YAP and those in which noncanonical functions of individual pathway components contribute to tumor suppression.
KeywordsCanonical Hippo pathway Noncanonical Hippo pathway liver cancer Oval cell Intestine cancer Tissue regeneration Lymphoma Genomic instability
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