Hippo in Cell Cycle and Mitosis

  • Norikazu Yabuta
  • Hiroshi NojimaEmail author


The Hippo pathway regulates cell growth and cell cycle-dependent ­processes, including mitosis, cell cycle checkpoints, mitotic checkpoints, and DNA damage response (DDR) checkpoints, thereby preventing the accumulation of abnormal cells with aneuploidy and polyploidy. Moreover, Mst1/2, Lats1/2, Mob1, and Rassf1A ­primarily colocalize with mitotic regulators, such as Aurora A and Polo, at the centrosome, and then dynamically translocate to the nucleus or the central spindle and the midbody in response to various stimuli. In particular, Lats1/2 play various roles in the DDR checkpoint, maintaining centrosome integrity, mitotic checkpoints (including the spindle assembly checkpoint (SAC)), mitotic exit, cytokinesis, EMT, and cellular senescence. Lats2 also plays a pivotal role in the cell cycle checkpoint via the p53 pathway, thereby functioning as another “guardian” of genome integrity. Therefore, the machinery and related molecules within the Hippo pathway may be potent and promising cancer therapy targets, which may arrest or kill malignant tumor cells without the side effects associated with commonly used treatments.


Hippo Cell cycle Checkpoint Mitosis Lats1/2 Chromosomal instability 



We thank Dr. Moshe Oren and Dr. Yael Aylon for inviting us to write this review. We also thank Dr. Patrick Hughes and Dr. Stephen Cooke (Bioedit Ltd.) for critically reading the manuscript.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Molecular Genetics, Research Institute for Microbial DiseasesOsaka UniversitySuita CityJapan
  2. 2.DNA-chip Development Center for Infectious Diseases, Research Institute for Microbial DiseasesOsaka UniversitySuita CityJapan

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