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Memory CD8+ T Cell Protection

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Crossroads Between Innate and Adaptive Immunity IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 785))

Abstract

Memory CD8+ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8+ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8+ T cell response will help optimize vaccine-induced CD8+ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8+ T cells may affect the primary response.

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Acknowledgments

This work was supported by grants R01AI048849, R01AI065544, and 5U19AI083008 to L.J.S. and P30CA006927 to FCCC. S.R. was supported by training grant T32 CA-009035036 to FCCC. We thank Holly Gillin for editorial help.

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  1. Immune Cell Development and Host Defense, The Research Institute of Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA

    Sanda Remakus Ph.D. & Luis J. Sigal D.V.M., Ph.D.

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  1. Sanda Remakus Ph.D.
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  2. Luis J. Sigal D.V.M., Ph.D.
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Correspondence to Luis J. Sigal D.V.M., Ph.D. .

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Editors and Affiliations

  1. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  2. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

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Remakus, S., Sigal, L.J. (2013). Memory CD8+ T Cell Protection. In: Katsikis, P., Schoenberger, S., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity IV. Advances in Experimental Medicine and Biology, vol 785. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6217-0_9

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