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The Interaction Between Filarial Parasites and Human Monocyte/Macrophage Populations

  • Roshanak Tolouei SemnaniEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 785)

Abstract

Lymphatic filariasis is a mafor tropical disease affecting approximately 120 million people worldwide. Patent infection, by and large, is clinically asymptomatic but is associated with the inability of T cells to proliferate or produce IFN-γ in response to parasite antigen. Monocyte dysfunction is one hypothesis felt to explain the lack of an antigen-specific T cell response. In fact, monocytes from filaria-infected individuals have been shown to be studded with internalized filarial antigens. Understanding how the phenotype and the function of these monocytes are altered through the internalization of these parasite antigens is one of the areas our laboratory has focused on. In fact, the existence and/or function of alternatively activated macrophages in murine models of filarial infections have been extensively studied. Whether this population of macrophages can be induced in human filarial infections is the main focus of this review.

Keywords

Human Alternatively activated macrophages Filarial parasites Monocytes Lymphatic filariasis 

Notes

Acknowledgments

This work was supported by the Intramural Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, and National Institutes of Health. We thank Brenda Rae Marshall, DPSS, NIAID, for editing.

Because I am a government employee and this is a government work, the work is in the public domain in the United States. Notwithstanding any other agreements, the NIH reserves the right to provide the work to PubMedCentral for display and use by the public, and PubMedCentral may tag or modify the work consistent with its customary practices. You can establish rights ­outside of the USA subfect to a government use license.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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