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Crossroads Between Innate and Adaptive Immunity IV pp 121–132Cite as

Targeting the Skin for Microneedle Delivery of Influenza Vaccine

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 785))

Abstract

Influenza infection represents a major socioeconomic burden worldwide. Skin represents a new target that has gained much attention in recent years for delivery of influenza vaccine as an alternative to the conventional intramuscular route of immunization. In this review we describe different microneedle vaccination approaches used in vivo, including metal and dissolving microneedle patches that have demonstrated promising results. Additionally we analyze the immunological basis for microneedle skin immunization and targeting of the skin’s dense population of antigen presenting cells, their role, characterization, and function. Additionally we analyze the importance of inflammatory signaling in the skin after microneedle delivery.

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Acknowledgements

We thank for the collaboration Dr. Mark R. Prausnitz, Dr. Vladimyr G. Zarnitsyn, Dr. Harvinder Singh Gill and Dr. Sean P. Sullivan, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA.

Research was supported by 1U01 AI074579-01/NIH and 1U01 EB012495/NIBIB grants.

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Authors and Affiliations

  1. Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Influenza Pathogenesis and Research Center (Emory University-UGA), 1518 Clifton Road, Atlanta, GA, 30322, USA

    Dimitrios G. Koutsonanos M.D., Richard W. Compans Ph.D. & Ioanna Skountzou M.D., Ph.D.

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  1. Dimitrios G. Koutsonanos M.D.
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  2. Richard W. Compans Ph.D.
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  3. Ioanna Skountzou M.D., Ph.D.
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Corresponding author

Correspondence to Ioanna Skountzou M.D., Ph.D. .

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Editors and Affiliations

  1. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  2. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

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Koutsonanos, D.G., Compans, R.W., Skountzou, I. (2013). Targeting the Skin for Microneedle Delivery of Influenza Vaccine. In: Katsikis, P., Schoenberger, S., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity IV. Advances in Experimental Medicine and Biology, vol 785. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6217-0_13

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