Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

  • Julie C. RibotEmail author
  • Bruno Silva-Santos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 785)


γδ T lymphocytes are major providers of the pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-17 (IL-17) at early stages of (auto)immune responses. We and others have recently described the phenotype and differentiation requirements of two distinct murine γδ T cell subsets producing either IFN-γ or IL-17. Here we summarize our current understanding of the molecular mechanisms that control γδ T cell differentiation, which is programmed in the thymus, and peripheral activation upon infection. We focus on the costimulatory receptors CD27 and CD28, which play independent and non-redundant roles in the physiology of γδ T cells in mice and in humans.


γδ T cells T cell activation Costimulation CD27 CD28 



We thank our colleagues and collaborators that have helped us to produce the data reviewed and to shape the ideas discussed here. Our research is funded by the European Research Council (StG_260352 to B.S.S.), European Molecular Biology Organization (Young Investigator Programme; B.S.S.), and Fundação para a Ciência e Tecnologia (post-doctoral fellowship to J.C.R.).


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Molecular Immunology Unit, Faculdade de Medicinal, Institutor de Medicinal MolecularUniversidade de LisboaLisbonPortugal

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