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Human T Follicular Helper Cells: Development and Subsets

  • Nathalie Schmitt
  • Hideki UenoEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 785)

Abstract

Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4+ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.

Keywords

Human T follicular helper cells CD4+ T cell subsets Antibody response Tonsils Blood CXCR5 Autoimmune diseases 

Notes

Acknowledgments

We thank former and current members of the Institute for their contributions to our progresses. These studies have been supported by the NIH (P01 CA084514, U19 AI057234, U19 AI082715, and U19 AI089987), the Baylor Health Care System; the Baylor Health Care System Foundation.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Baylor Institute for Immunology ResearchDallasUSA

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