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Vita-PAMPs: Signatures of Microbial Viability

  • Diego Mourao-Sa
  • Soumit Roy
  • J. Magarian BlanderEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 785)

Abstract

Can the innate immune system detect and respond to microbial viability? Using bacteria as a model, we found that indeed the very essence of microbial infectivity, viability itself, can be detected, and notably, in the absence of the activity of virulence factors. The microbial molecule that serves as the signature of viability is bacterial messenger RNA (mRNA), common to all bacteria, and without which bacteria cannot survive. Prokaryotic mRNAs also differ from eukaryotic mRNAs in several ways, and as such, these features all fulfill the criteria, and more, for a pathogen-associated molecular pattern (PAMP) as originally proposed by Charles Janeway. Because these mRNAs are lost from dead bacteria, they belong to a special class of PAMPs, which we call vita-PAMPs. Here we discuss the possible receptors and pathways involved in the detection of bacterial mRNAs, and thus microbial viability. We also consider examples of vita-PAMPs other than bacterial mRNA.

Keywords

Pattern recognition Vaccine Bacterial messenger RNA Virulence ­factors Toll-like receptor Inflammasome Type I interferon 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Diego Mourao-Sa
    • 1
  • Soumit Roy
    • 1
  • J. Magarian Blander
    • 1
    Email author
  1. 1.Department of MedicineImmunology Institute, Mount Sinai School of MedicineNew YorkUSA

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