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Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation

  • Victoria Scott
  • Colin H. Brown
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 784)

Abstract

Circulating oxytocin is critical for normal birth and lactation. Oxytocin is synthesised by hypothalamic supraoptic and paraventricular neurons and is released from the posterior pituitary gland into the circulation. Oxytocin secretion depends on action potentials initiated at the cell body, and we have shown that intravenous (IV) administration of kisspeptin-10 transiently increases the firing rate of supraoptic nucleus oxytocin neurons in anaesthetised, non-pregnant, pregnant and lactating rats. This peripheral effect is likely via vagal afferent input, because disruption of vagal afferents prevented the excitation. In our initial studies, intracerebroventricular (icv) administration of kisspeptin-10 did not alter the firing rate of oxytocin neurons in non-pregnant rats. Remarkably, we have now gathered unpublished observations showing that icv kisspeptin-10 transiently excites oxytocin neurons in late pregnancy and during lactation, suggesting that a central kisspeptin excitation of oxytocin neurons emerges at the end of pregnancy, when increased oxytocin secretion is required for delivery of the fetus and for milk let-down after delivery.

Keywords

Firing Rate GnRH Neuron Posterior Pituitary Gland Magnocellular Neuron Milk Ejection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Funded by a New Zealand Health Research Council Project Grant (VS and CHB) and a University of Otago Health Sciences Fellowship (VS). We also thank Dr Rebecca Campbell for constructive criticism of an earlier version of the manuscript.

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Centre for Neuroendocrinology and Department of PhysiologyUniversity of OtagoDunedinNew Zealand

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