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How Can We Overcome the Biological Inertia of Past Deprivation? Anthropological Perspectives on the Developmental Origins of Adult Health

  • Christopher W. KuzawaEmail author
Part of the National Symposium on Family Issues book series (NSFI)

Abstract

Due in large part to work by David Barker and his colleagues, it is now widely accepted that prenatal nutrition modifies early development, and in so doing, influences adult biology and risk of disease. Much of this research has emphasized the limited capacity of the mother’s body to buffer the fetus from stressors which may impair early development and lead to long-term health deficits. Developmental impairment may help explain some of the relationships observed between birth size and adult health. However, many biological responses initiated in utero are not due to damage but instead reflect regulatory changes in the body’s metabolic or biological priorities. Some of these developmental sensitivities may have evolved to allow a fetus to use maternal cues to adjust biological settings in anticipation of postnatal environmental conditions. This hypothesis is supported by evidence that fetal ­nutrition is buffered against short-term fluctuations in maternal intake during pregnancy, while it shows sensitivity to a mother’s lifelong nutritional experience. By calibrating fetal nutrition to the mother’s average nutritional experiences, maternal metabolism could provide offspring with a reliable estimate of nutritional conditions likely to be experienced in the future. In humans, maternal buffering of fetal nutrition is predicted to limit the deleterious impact of nutritional stress experienced by the mother during pregnancy while also attenuating the health benefits of short-term pregnancy supplements. Designing interventions that mimic sustained improvement in environmental conditions may therefore be needed to optimize health in future generations.

Keywords

Maternal Separation Developmental Plasticity Biological Setting Nutritional Experience Fetal Nutrition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Barker, D. (1994). Mothers, babies, and disease in later life. London: BMJ Publishing.Google Scholar
  2. Barker, D. J., Osmond, C., Golding, J., Kuh, D., & Wadsworth, M. E. (1989). Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. British Medical Journal, 298(6673), 564–567.CrossRefGoogle Scholar
  3. Bateson, P. (2001). Fetal experience and good adult design. International Journal of Epidemiology, 30(5), 928–934.CrossRefGoogle Scholar
  4. Bateson, P., Barker, D., Clutton-Brock, T., Deb, D., D’Udine, B., Foley, R. A., et al. (2004). Developmental plasticity and human health. Nature, 430(6998), 419–421.CrossRefGoogle Scholar
  5. Boiko, J., Jaquet, D., Chevenne, D., Rigal, O., Czernichow, P., & Levy-Marchal, C. (2005). In situ lipolytic regulation in subjects born small for gestational age. International Journal of Obesity (London), 29(6), 565–570.CrossRefGoogle Scholar
  6. Franklin, T. B., Russig, H., Weiss, I. C., Graff, J., Linder, N., Michalon, A., et al. (2010). Epigenetic transmission of the impact of early stress across generations. Biological Psychiatry, 68(5), 408–415.CrossRefGoogle Scholar
  7. Gluckman, P. D., & Hanson, M. (2005). The fetal matrix: Evolution, development, and disease/Peter Gluckman, Mark Hanson. New York, NY: Cambridge University Press.Google Scholar
  8. Hales, C., & Barker, D. (1992). Type 2 (non-insulin dependent) diabetes mellitus: The thrifty phenotype hypothesis. Diabetologia, 35, 595–601.CrossRefGoogle Scholar
  9. Kramer, M. S., & Kakuma, R. (2003). Energy and protein intake in pregnancy. Cochrane Database Systematic Review (4), CD000032.Google Scholar
  10. Kuzawa, C. W. (1998). Adipose tissue in human infancy and childhood: An evolutionary perspectives. Yearbook of Physical Anthropology, 41, 177–209.CrossRefGoogle Scholar
  11. Kuzawa, C. W. (2005). Fetal origins of developmental plasticity: are fetal cues reliable predictors of future nutritional environments? American Journal of Human Biology, 17(1), 5–21.CrossRefGoogle Scholar
  12. Kuzawa, C. W. (2008). The developmental origins of adult health: Intergenerational inertia in adaptation and disease. In W. Trevathan, E. Smith, & J. McKenna (Eds.), Evolutionary medicine and health: New perspectives (pp. 325–349). New York: Oxford University Press.Google Scholar
  13. Kuzawa, C. W. (2010). Beyond feast-famine: Brain evolution, human life history, and the metabolic syndrome. In M. Muehlenbein (Ed.), Human evolutionary biology. Cambridge: Cambridge University Press.Google Scholar
  14. Kuzawa, C. W., McDade, T. W., Adair, L. S., & Lee, N. (2010). Rapid weight gain after birth predicts life history and reproductive strategy in Filipino males. Proceedings of the National Academy of Sciences, 107(39), 16800–16805.CrossRefGoogle Scholar
  15. Kuzawa, C. W., & Pike, I. L. (2005). Introduction. Fetal origins of developmental plasticity. American Journal of Human Biology, 17(1), 1–4.CrossRefGoogle Scholar
  16. Kuzawa, C. W., & Quinn, E. (2009). Developmental origins of adult function and health: Evolutionary hypotheses. Annual Review of Anthropology, 38, 131–147.CrossRefGoogle Scholar
  17. Kuzawa, C. W., & Thayer, Z. (2011). Timescales of human adaptation: The role of epigenetic processes. Epigenomics, 3(2), 221–234.CrossRefGoogle Scholar
  18. Lampl, M., Kuzawa, C. W., & Jeanty, P. (2002). Infants thinner at birth exhibit smaller kidneys for their size in late gestation in a sample of fetuses with appropriate growth. American Journal of Human Biology, 14(3), 398–406.CrossRefGoogle Scholar
  19. Lasker, G. (1969). Human biological adaptability: The ecological approach in physical anthropology. Science, 166, 1480–1486.CrossRefGoogle Scholar
  20. Mackenzie, H. S., & Brenner, B. M. (1995). Fewer nephrons at birth: A missing link in the etiology of essential hypertension? American Journal of Kidney Diseases, 26(1), 91–98.CrossRefGoogle Scholar
  21. McDade, T. W., Rutherford, J., Adair, L., & Kuzawa, C. W. (2010). Early origins of inflammation: Microbial exposures in infancy predict lower levels of C-reactive protein in adulthood. Proceedings of the Biological Society, 277(1684), 1129–1137.CrossRefGoogle Scholar
  22. Weaver, I. C., Cervoni, N., Champagne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7(8), 847–854.CrossRefGoogle Scholar
  23. Wells, J. C. (2003). The thrifty phenotype hypothesis: Thrifty offspring or thrifty mother? Journal of Theoretical Biology, 221(1), 143–161.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Anthropology and Institute for Policy ResearchNorthwestern UniversityEvanstonUSA

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