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Pyoderma Gangrenosum

  • Liam Zakko
  • Justin Finch
  • Marti J. Rothe
  • Jane M. Grant-Kels
Chapter

Abstract

Clinical signs and features include:

Four clinical varieties:

Classical: painful deep ulcer with a violaceous, undermined border and necrotic, purulent center; can start as papule and progress to ulcer

Pustular: painful, sterile pustule with no ulcerative progression

Bullous: presents as a tense bulla that rapidly progresses to an ulcer

Vegetative: superficial ulcer that progresses to a vegetative/exophytic lesion

Seventy percent of lesions on lower extremity, but can be at any skin location (often peristomal)

Often exhibits pathergy

Among patients with ulcerative colitis, 0.5–20 % develop pyoderma gangrenosum (PG) usually during a flare

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Mycophenolate Mofetil Pyoderma Gangrenosum Erythema Multiforme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Timani S, Mutasim DF. Skin manifestations of inflammatory bowel disease. Clin Dermatol. 2008;26:265–73.PubMedCrossRefGoogle Scholar
  2. 2.
    Larsen S, Bendtzen K, Nielsen OH. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann Med. 2010;42:97–114.PubMedCrossRefGoogle Scholar
  3. 3.
    Dabade TS, Davis MD. Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet’s syndrome). Dermatol Ther. 2011;24:273–84.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Liam Zakko
    • 1
  • Justin Finch
    • 2
  • Marti J. Rothe
    • 2
  • Jane M. Grant-Kels
    • 2
  1. 1.Yale Department of Internal MedicineYale New Haven HospitalNew HavenUSA
  2. 2.Department of DermatologyUniversity of Connecticut Health CenterFarmingtonUSA

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