Pyoderma Gangrenosum

  • Liam Zakko
  • Justin Finch
  • Marti J. Rothe
  • Jane M. Grant-Kels


Clinical signs and features include:

Four clinical varieties:

Classical: painful deep ulcer with a violaceous, undermined border and necrotic, purulent center; can start as papule and progress to ulcer

Pustular: painful, sterile pustule with no ulcerative progression

Bullous: presents as a tense bulla that rapidly progresses to an ulcer

Vegetative: superficial ulcer that progresses to a vegetative/exophytic lesion

Seventy percent of lesions on lower extremity, but can be at any skin location (often peristomal)

Often exhibits pathergy

Among patients with ulcerative colitis, 0.5–20 % develop pyoderma gangrenosum (PG) usually during a flare


Fatigue Arthritis Lithium Flare Methotrexate 


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    Larsen S, Bendtzen K, Nielsen OH. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann Med. 2010;42:97–114.PubMedCrossRefGoogle Scholar
  3. 3.
    Dabade TS, Davis MD. Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet’s syndrome). Dermatol Ther. 2011;24:273–84.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Liam Zakko
    • 1
  • Justin Finch
    • 2
  • Marti J. Rothe
    • 2
  • Jane M. Grant-Kels
    • 2
  1. 1.Yale Department of Internal MedicineYale New Haven HospitalNew HavenUSA
  2. 2.Department of DermatologyUniversity of Connecticut Health CenterFarmingtonUSA

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