Abstract
Gardner syndrome is genetic disease characterized by adenomatous polyps of the gastrointestinal (GI) tract associated with tumors outside of the colon. Failure to remove the colon results in a very high risk of cancer.
GI symptoms include:
Rectal bleeding, anemia
Change in bowel habits (constipation or diarrhea)
Abdominal pain
Palpable abdominal masses
Weight loss
Clinical signs and findings include:
Variant of familial adenomatous polyposis
Classically, hundreds to thousands of polyps throughout the colon. Polyps begin to develop as intramucosal nodules in early childhood in the rectosigmoid colon. By adolescence, they have spread throughout the colon. Fifty percent develop adenomas by age 15–95 % by age 35.
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Zakko, L. (2013). Gardner’s Syndrome: Gastrointestinal Features. In: Wu, G., Selsky, N., Grant-Kels, J. (eds) Atlas of Dermatological Manifestations of Gastrointestinal Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6191-3_41
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DOI: https://doi.org/10.1007/978-1-4614-6191-3_41
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