Vitiligo

Abstract

Clinical signs and features include:

Well-circumscribed depigmented macules and patches, which often increase with time

Often occurs at typically hyperpigmented sites (face, dorsal surface of the hands, nipples, axillae, umbilicus, sacrum, inguinal, anogenital regions)

Lesions occasionally may itch, all have a propensity for sunburn, may exhibit Koebner phenomenon developing in areas of friction (elbows, knees, digits, flexor wrists)

Localized—focal, segmental (dermatomal) or mucosal—often in trigeminal dermatome

Generalized: acrofacial, vulgaris, mixed

Universal: >80 % of the body

Ponctué: rare, discrete, confetti macules

Trichrome: tan zone of varying width between normal and depigmented skin