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Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer

  • Nicholas Lamparella
  • Amit Barochia
  • Salah Almokadem
Part of the Advances in Experimental Medicine and Biology book series (volume 779)

Abstract

Non-small cell lung cancer represents a group of heterogeneous diseases. The last decade witnessed significant progress in improving our understanding of the biology of non-small cell lung cancer, which led to the identification of several genetic targets. Those genetic targets were utilized to explain clinical phenomena, such as the occurrence of non-small cell lung cancer in never-smokers, to predict response to conventional chemotherapy and biological agents, and to explain and predict resistance to therapy. The progress in the treatment of non-small cell lung cancer in the last few years was based on a new generation of population-enriched clinical trials that utilized genetic targets such as somatic EGFR mutations and ALK-EML4 mutations. In this review we will discuss the available information about the key genetic markers of non-small cell lung cancer and the pivotal clinical trials that validate the use of those genetic markers in non-small cell lung cancer patients.

Keywords

Non-small cell lung cancer EGFR Erlotinib Gefitinib Affitinib Cetuximab ALK Crizotinib MET Tivantinib MetMab ROS1 VEGF Bevacizumab 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Nicholas Lamparella
    • 1
  • Amit Barochia
    • 1
  • Salah Almokadem
    • 1
  1. 1.Department of MedicinePenn State Hershey Medical CenterHersheyUSA

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