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Impact of Genetic Targets on Prostate Cancer Therapy

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Impact of Genetic Targets on Cancer Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((volume 779))

Abstract

Given the global incidence of prostate cancer and its sociological impact, it remains a challenging disease to clinicians and researchers alike. In the last few years several new drugs have been added to the armamentarium of prostate cancer therapy and offers survival benefit to patients with prostate cancer. However, effective drugs are still needed that offer extended survival benefit and alter the natural history of the disease. Recent efforts have focused on better understanding the underlying biology and genetic heterogeneity of the disease and identified novel targets that can be utilized for drug development and therapeutics in the future. In this review we present an overview of the genetic landscape of prostate cancer, novel targets in the prostate cancer therapy and the results of key clinical trials of these novel drugs.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Penn State University, Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA

    Hassan Sheikh M.D. & Alan Lipton M.D.

  2. Department of Medicine (Hematology/Oncology), Penn State Hershey Medical Center, Penn State Hershey Cancer Institute, Penn State College of Medicine, 500 University Drive, Mail Code H091, Hershey, PA, 17033-0850, USA

    Junaid Abdulghani M.D. Ph.D.

  3. Lebanon VA Hospital, Lebanon, PA, USA

    Suhail Ali M.D.

  4. Department of Biochemistry and Molecular Biology, Penn State Hershey Cancer Institute, 500 University Drive, Hershey, PA, 17033, USA

    Raghu Sinha Ph.D.

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  1. Hassan Sheikh M.D.
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  2. Junaid Abdulghani M.D. Ph.D.
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  3. Suhail Ali M.D.
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  4. Raghu Sinha Ph.D.
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  5. Alan Lipton M.D.
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Correspondence to Alan Lipton M.D. .

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    Wafik S El-Deiry

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Sheikh, H., Abdulghani, J., Ali, S., Sinha, R., Lipton, A. (2013). Impact of Genetic Targets on Prostate Cancer Therapy. In: El-Deiry, W. (eds) Impact of Genetic Targets on Cancer Therapy. Advances in Experimental Medicine and Biology, vol 779. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6176-0_17

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