Genetic Component of Oxidative Stress in Rheumatoid Arthritis

  • F. David Carmona
  • Jose-Ezequiel Martin
  • Javier Martin
Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

There are increasing evidences pointing to a crucial role of the redox control in the maintenance of self-tolerance, and oxidative stress is emerging as a key factor contributing to susceptibility and progression of a wide spectrum of autoimmune diseases. For instance, oxidative stress at sites of chronic inflammation has been associated with the course of rheumatoid arthritis (RA) patients. Nevertheless, very little is known about the possible genetic background of oxidative stress that leads to pathologic conditions like RA despite the large genome-wide association studies performed during the last years. There are some genes that clearly represent good candidates to be important players in the pathophysiology of diseases influenced by oxidative stress. These include nuclear genes like HIF1A, MSRA, HO1, p53, NCF1, and NOS2A but also mitochondrial genes. Here we shall review the current knowledge about the molecular mechanisms affected by oxidative stress situations and will give some clues of how these changes may contribute to the development and progression of RA.

Keywords

Fatigue Migration Arthritis Peroxide Glutathione 

Abbreviations

ACPA

Anti-citrullinated protein autoantibodies

ASK1

Apoptosis signal-regulating kinase 1

ATP

Adenosine triphosphate

DNA

Deoxyribonucleic acid

GWAS

Genome-wide association study

HIF-1α

Inducible factor-1 α

HIPK1

Homeodomain-interacting protein kinase 1

HO-1

Heme oxygenase-1

LDL

Low-density lipoprotein

MSRA

Methionine sulfoxide reductase A

mtDNA

Mitochondrial deoxyribonucleic acid

NADH

Nicotinamide adenine dinucleotide

NCF1

Neutrophil cytosolic factor 1

NF-κB

Nuclear factor-κB

RA

Rheumatoid arthritis

Redox

Reduction–oxidation

RNS

Reactive nitrogen species

ROS

Reactive oxygen species

SENP1

Sentrin-specific protease 1

SUMO

Small ubiquitin-like modifier

TNFR

Tumor necrosis factor receptor

TNF-α

Tumor necrosis factor alpha

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • F. David Carmona
    • 1
  • Jose-Ezequiel Martin
    • 1
  • Javier Martin
    • 1
  1. 1.Instituto de Parasitología y Biomedicina López Neyra, ArmillaGranadaSpain

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