Antioxidants in the Treatment of Osteoarthritis and Bone Mineral Loss

  • Ali Mobasheri
  • Mehdi Shakibaei
  • Hans Konrad Biesalski
  • Yves Henrotin
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


The concept that inflammatory diseases of bones and joints can be postponed or even prevented naturally by consuming certain foods or food-derived substances is currently eliciting considerable interest from researchers, clinicians and patients. Oxidative stress results in the production of reactive oxygen species (ROS), which play important roles in the development of many diseases including those relating to bones and joints. Metabolic reactions in osteoblasts, osteoclasts, chondrocytes and synoviocytes produce free radicals, ROS and their derivatives. These dangerous chemicals can accumulate in bones and synovial joints, and in combination with inflammatory mediators they can cause extensive structural damage, inflammation and cell death. Antioxidants are naturally occurring reducing agents capable of inhibiting ROS formation, scavenging free radicals and removing ROS derivatives. Antioxidant vitamins have major roles in modulating oxidative stress, regulating immune responses and contributing to cell differentiation. Vitamin C (ascorbic acid), vitamin E, thiols (glutathione) and plant polyphenols have the capacity to neutralize ROS in joints and decrease the oxidative stress associated with the progression of arthritis. This chapter focuses on antioxidants and their potential for the treatment of diseases of bones and joints, particularly focusing on osteoarthritis (OA) and bone mineral loss.


Reactive Oxygen Species Articular Cartilage Subchondral Bone European Food Safety Authority Antioxidant Vitamin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Activator protein 1


Androgen receptor


Bone mineral density


CREB-binding protein or CREBBP


Centers for Disease Control and Prevention


current Good Manufacturing Practices




European Food Safety Authority


Early growth response protein 1


Endothelial NOS


Electrophile-responsive element


Fatty acids


Food and Drug Administration


Glutathione or gamma-l-glutamyl-l-cysteinylglycine


Hydrogen peroxide


Interferon gamma


Insulin-like growth factor I


Insulin-like growth factor I receptor


Interleukin 1 beta


Inducible NOS


Joint space width








Nicotinamide adenine dinucleotide phosphate


Pyrin-like protein containing a pyrin domain


Nuclear factor kappa B


National Institute of Arthritis and Musculoskeletal and Skin Diseases


Nitric oxide


Nitric oxide synthase


Nuclear respiratory factor 2


Nonsteroidal anti-inflammatory drug




E1A binding protein p300


Protein 53 or tumour protein 53


Prostaglandin E2


Peroxisome proliferator-activated receptor gamma


Apoptosis-associated speck-like protein containing a caspase-recruitment domain (CARD)


Rheumatoid arthritis


Receptor activator of nuclear factor kappa B


Receptor activator of nuclear factor kappa B ligand


Reactive oxygen species


Sirtuin (silent mating type information regulation 2 homolog) 1


Systemic lupus erythematosus


Superoxide dismutase


Signal transducer and activator of transcription


Transforming growth factor beta


United Nations


World Health Organization



A. Mobasheri wishes to acknowledge the financial support of the Wellcome Trust, the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) (grant number: Mobasheri.A.28102007), the Biotechnology and Biological Sciences Research Council (BBSRC) (grants BBSRC/S/M/2006/13141 and BB/G018030/1) and the Engineering and Physical Sciences Research Council (EPSRC). A. Mobasheri and Y. Henrotin are members of the D-BOARD Consortium funded by European Commission Framework 7 program (EU FP7; HEALTH.2012.2.4.5–2, project number 305815, NovelDiagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases).


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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Ali Mobasheri
    • 1
  • Mehdi Shakibaei
    • 2
  • Hans Konrad Biesalski
    • 3
  • Yves Henrotin
    • 4
    • 5
  1. 1.Musculoskeletal Research Group, Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health SciencesThe University of NottinghamLeicestershireUK
  2. 2.Musculoskeletal Research Group, Institute of AnatomyLudwig-Maximilian-University MunichMunichGermany
  3. 3.Department of Biological Chemistry and Nutrition, Institute of Biological Chemistry and NutritionUniversity of HohenheimStuttgartGermany
  4. 4.Bone and Cartilage Research Unit, Institute of PathologyUniversity of Liege, Sart-TilmanLiegeBelgium
  5. 5.Physical Therapy and Rehabilitation DepartmentPrincess Paola Hospital, VivaliaMarche-en-FamenneBelgium

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