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Heart Valves pp 261-280 | Cite as

Tissue-Engineered Heart Valves

  • Jillian B. Schmidt
  • Robert T. Tranquillo
Chapter

Abstract

A tissue engineered heart valve (TEHV) could serve as a living, implantable valve replacement that would grow and adapt with the patient. A TEHV consists of relevant cells seeded on or entrapped in a scaffold material which is designed to degrade as the cells produce their own extracellular matrix components. Because the valve consists of living tissue, it can grow and remodel as a patient ages, making it an especially attractive replacement option for pediatric and young adult patients. To date, using various cell sources, scaffold materials, and/or in vitro culture protocols, several laboratories have produced TEHVs with the appropriate geometry and near-native mechanical properties. TEHVs implanted in the pulmonary position in sheep in our laboratory have shown promising short-term functionality but fail to maintain good performance after several months in vivo. Upcoming TEHV research will focus on optimization of TEHV components and in vitro culture conditions in order to improve long-term function post-implant, with the hope of performing human implants in the future.

Keywords

Particle Image Velocimetry Heart Valve Scaffold Material Ovine Model Mechanical Conditioning 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

αSMA

α-Smooth muscle actin

CFD

Computational fluid dynamics

DPD

Diastolic pulse duplicator

EC

Endothelial cells

ECM

Extracellular matrix

EPC

Endothelial progenitor cells

FSF

Flex-stretch-flow

FSI

Fluid–structure interaction

GAG

Glycosaminoglycan

MSC

Mesenchymal stem cells

nhDF

Neonatal human dermal fibroblasts

P4HB

Poly-4-hydroxybutyrate

PEGDA

Polyethylene glycol diacrylate

PGA

Polyglycolic acid

PIV

Particle image velocimetry

PLA

Polylactic acid

PLGA

Poly(lactic-co-glycolic acid)

PLLA

Poly-l-lactide

SMC

Smooth muscle cells

TEHV

Tissue engineered heart valve

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Chemical Engineering and Materials ScienceUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Biomedical EngineeringUniversity of MinnesotaMinneapolisUSA

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