Taurine 8 pp 111-119 | Cite as

Taurine Counteracts the Suppressive Effect of Lipopolysaccharide on Neurogenesis in the Hippocampus of Rats

  • Gaofeng Wu
  • Takashi Matsuwaki
  • Yoshinori Tanaka
  • Keitaro Yamanouchi
  • Jianmin HuEmail author
  • Masugi NishiharaEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)


Neurogenesis has been generally accepted to happen in the subventricular zone lining the lateral ventricular and subgranular zone (SGZ) in the hippocampus of adult mammalian brain. Recent studies have reported that inflammatory stimuli, such as injection of lipopolysaccharide (LPS), impair neurogenesis in the SGZ. Taurine, a sulfur-containing β-amino acid, is a major free intracellular amino acid in many tissues of mammals and having various supplementary effects on the mammalian body functions including the brain. Recently, it has been also reported that taurine levels in the brain significantly increase under stressful conditions. The present study was aimed to evaluate the possible beneficial effects of taurine on the neurogenesis in the SGZ under the condition of acute inflammatory stimuli by LPS. Adult male rats were intraperitoneally injected with taurine once a day for 39 days. Twenty-four hours before the animals were sacrificed on the last day of taurine treatment, LPS was injected simultaneously with bromodeoxyuridine (BrdU). Immunohistochemistry for BrdU, Ki67, and Iba-1 in the brain was performed, and serum levels of TNF-α and IL-1β 2 h after LPS injection were determined. The results showed that LPS significantly decreased the number of immunoreactive cells for both BrdU and Ki67 in the SGZ, while increased that for Iba-1, all of which were restored by taurine administration. Meanwhile, the serum concentrations of TNF-α and IL-1β were significantly increased, which were significantly attenuated by taurine administration. These results suggest that taurine effectively maintains neurogenesis in the SGZ under the acute infectious condition by attenuating the increase of microgliosis in the hippocampus as well as proinflammatory cytokines in the peripheral circulation.


Dentate Gyrus Newborn Neuron Subgranular Zone Taurine Level Adult Mammalian Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Central nervous system


Subgranular zone






Blood–brain barrier


Subventricular zone


Dentate gyrus


Tumor necrosis factor-α





This work was supported in part by the project of JSPS Fellowship for Researcher in JAPAN (2010 long term) to GW and a Grant-in-Aid for Scientific Research (23228004) from the JSPS to MN.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Gaofeng Wu
    • 1
    • 2
  • Takashi Matsuwaki
    • 1
  • Yoshinori Tanaka
    • 1
  • Keitaro Yamanouchi
    • 1
  • Jianmin Hu
    • 2
    Email author
  • Masugi Nishihara
    • 1
    Email author
  1. 1.Department of Veterinary PhysiologyGraduate School of Agricultural and Life Sciences, The University of TokyoTokyoJapan
  2. 2.College of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyangP.R. China

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