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Taurine 8 pp 85-99 | Cite as

Taurine Regulation of Voltage-Gated Channels in Retinal Neurons

  • Matthew J. M. Rowan
  • Simon Bulley
  • Lauren A. Purpura
  • Harris Ripps
  • Wen ShenEmail author
Conference paper
  • 2.2k Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

Taurine activates not only Cl-permeable ionotropic receptors but also receptors that mediate metabotropic responses. The metabotropic property of taurine was revealed in electrophysiological recordings obtained after fully blocking Cl-permeable receptors with an inhibitory “cocktail” consisting of picrotoxin, SR95531, and strychnine. We found that taurine’s metabotropic effects regulate voltage-gated channels in retinal neurons. After applying the inhibitory cocktail, taurine enhanced delayed outward rectifier K+ channels preferentially in Off-bipolar cells, and the effect was completely blocked by the specific PKC inhibitor, GF109203X. Additionally, taurine also acted through a metabotropic pathway to suppress both L- and N-type Ca2+ channels in retinal neurons, which were insensitive to the potent GABAB receptor inhibitor, CGP55845. This study reinforces our previous finding that taurine in physiological concentrations produces a multiplicity of metabotropic effects that precisely govern the integration of signals being transmitted from the retina to the brain.

Keywords

Bipolar Cell Channel Current Amacrine Cell GABAB Receptor Retinal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AMPA

α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid

GABA

γ-Aminobutyric acid

IPL

Inner plexiform layer

ONL

Outer nuclear layer

INL

Inner nuclear layer

GCL

Ganglion cell layer

Notes

Acknowledgments

This work was supported by research grants to W.S. from NSF (1021646) and NIH (EY14161).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Matthew J. M. Rowan
    • 1
  • Simon Bulley
    • 1
  • Lauren A. Purpura
    • 1
  • Harris Ripps
    • 2
    • 3
  • Wen Shen
    • 1
    Email author
  1. 1.Department of Biomedical ScienceCharles E Schmidt College of Medicine, Florida Atlantic UniversityBoca RatonUSA
  2. 2.Department of Ophthalmology and Visual SciencesUniversity of Illinois College of MedicineChicagoUSA
  3. 3.Marine Biological LaboratoryWoods HoleUSA

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