Taurine 8 pp 437-448 | Cite as

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

  • Atcharaporn Thaeomor
  • J. Michael Wyss
  • Stephen W. Schaffer
  • Wiyada Punjaruk
  • Krissada Vijitjaroen
  • Sanya Roysommuti
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

In adult rats, perinatal taurine depletion followed by high sugar intake alters neural and renal control of arterial pressure via the renin–angiotensin system. This study tests the hypothesis that perinatal taurine supplementation predisposes adult female rats to the adverse arterial pressure effect of high sugar intake via the renin–angiotensin system, rather than via estrogen. Female Sprague-Dawley rats were fed normal rat chow with 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Their female offspring were fed normal rat chow with either 5% glucose in tap water (TSG, CG) or tap water alone (TSW, CW). At 7–8 weeks of age, the female offspring’s renin–angiotensin system or estrogen receptors were inhibited by captopril or tamoxifen, respectively. Body weight, heart weight, kidney weight, mean arterial pressures (MAP), and heart rates were not significantly different among groups without captopril or tamoxifen. Captopril (but not tamoxifen) decreased MAP but not heart rates in all groups. In TSG compared to TSW, CW, and CG groups, baroreflex sensitivity of heart rate (BSHR) and renal nerve activity (BSRA) were significantly decreased. Neither captopril nor tamoxifen altered BSHR in TSG, but tamoxifen (but not captopril) restored TSG BSRA to CW or CG control levels. Perinatal taurine supplementation did not disturb sympathetic and parasympathetic nerve activity in the adult rats on high or basal sugar intake. Compared to its effect in CW and CG groups, tamoxifen increased sympathetic but decreased parasympathetic activity less in TSG and TSW groups. Inhibition of the renin–angiotensin system did not affect autonomic nerve activity in any group. These data suggest that in adult female rats that are perinatally supplemented with taurine, high sugar intake after weaning blunts arterial baroreflex via an estrogen (but not renin–angiotensin) mechanism.

Keywords

Sugar Obesity Catheter Estrogen Tyrosine 

Abbreviations

CW

Control with water intake alone

CW + Cap

CW plus captopril treatment

CW + Tam

CW plus tamoxifen treatment

CG

Control with high sugar intake

CG + Cap

CG plus captopril treatment

CG + Tam

CG plus tamoxifen treatment

TSW

Perinatal taurine supplementation with water intake alone

TSW + Cap

TSW plus captopril treatment

TSW + Tam

TSW plus tamoxifen treatment

TSG

Perinatal taurine supplementation with high sugar intake

TSG + Cap

TSG plus captopril treatment

TSG + Tam

TSG plus tamoxifen treatment

SD

Sprague-Dawley

HF

High frequency

LF

Low frequency

Notes

Acknowledgment

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Atcharaporn Thaeomor
    • 1
    • 2
  • J. Michael Wyss
    • 3
  • Stephen W. Schaffer
    • 4
  • Wiyada Punjaruk
    • 1
  • Krissada Vijitjaroen
    • 1
  • Sanya Roysommuti
    • 1
  1. 1.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  2. 2.School of Physiology, Institute of ScienceSuranaree University of TechnologyNakhonratchasimaThailand
  3. 3.Department of Cell, Developmental and Integrative Biology, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Department of Pharmacology, College of MedicineUniversity of South AlabamaMobileUSA

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