Taurine 8 pp 311-320 | Cite as

Antidiabetic Effect of Taurine in Cultured Rat Skeletal L6 Myotubes

  • Sun Hee Cheong
  • Kyung Ja ChangEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)


Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid, is found in all animal cells at millimolar concentrations and has been reported to show various health promoting activities including antidiabetic properties. The beneficial effects of taurine in diabetes mellitus have been known. However, the exact mechanism of hypoglycemic action of taurine is not properly defined. In this study, we investigated antidiabetic effect of taurine in the cell culture system using rat skeletal muscle cells. In cultured rat skeletal L6 myotubes, we studied the effect of taurine (0–100 μM) on glucose uptake to plasma membrane from the aspects of AMP-activated protein kinase (AMPK) signaling. Taurine stimulated glucose uptake in a dose-dependent manner by activating AMPK signaling. From these results, it may suggest that taurine show antidiabetic effect by stimulating insulin-independent glucose uptake in rat skeletal muscle.


Glucose Uptake Wako Pure Chemical Industry Antidiabetic Effect Increase Glucose Uptake Stimulate Glucose Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



AMP-activated protein kinase


Phosphatidylinositol-3 kinase


Glucose transporter 4


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Applied Biological ChemistryTokyo University of Agriculture and TechnologyFuchuJapan
  2. 2.Department of Food and NutritionInha UniversityIncheonKorea

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