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Taurine 8 pp 19-27 | Cite as

Taurine and Its Neuroprotective Role

  • Neeta Kumari
  • Howard PrenticeEmail author
  • Jang-Yen WuEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

Taurine plays multiple roles in the CNS including acting as a ­neuro-modulator, an osmoregulator, a regulator of cytoplasmic calcium levels, a trophic factor in development, and a neuroprotectant. In neurons taurine has been shown to prevent mitochondrial dysfunction and to protect against endoplasmic reticulum (ER) stress associated with neurological disorders. In cortical neurons in culture taurine protects against excitotoxicity through reversing an increase in levels of key ER signaling components including eIF-2-alpha and cleaved ATF6. The role of communication between the ER and mitochondrion is also important and examples are presented of protection by taurine against ER stress together with prevention of subsequent mitochondrial initiated apoptosis.

Keywords

Endoplasmic Reticulum Stress Unfold Protein Response Intracellular Free Calcium Taurine Level Taurine Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biomedical ScienceCharles E. Schmidt College of Medicine, Florida Atlantic UniversityBoca RatonUSA

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