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Taurine 8 pp 227-236 | Cite as

Thiotaurine Prevents Apoptosis of Human Neutrophils: A Putative Role in Inflammation

  • Elisabetta Capuozzo
  • Laura Pecci
  • Alessia Baseggio Conrado
  • Mario FontanaEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

Thiotaurine, a metabolic product of cystine, contains a sulfane sulfur atom that can be released as H2S, a gaseous molecule with a regulatory activity on inflammatory responses. The influence of thiotaurine on human leukocyte spontaneous apoptosis has been evaluated by measuring caspase-3 activity in human neutrophils. Addition of 100 μM thiotaurine induced a 55% inhibition of caspase-3 activity similar to that exerted by 100 μM H2S. Interestingly, in the presence of 1 mM GSH, an increase of the inhibition of apoptosis by thiotaurine has been observed. These results indicate that the bioactivity of thiotaurine can be modulated by GSH, which promotes the reductive breakdown of the thiosulfonate generating H2S and hypotaurine. As thiotaurine is able to incorporate reversibly reduced sulfur, it is suggested that the biosynthesis of this thiosulfonate could be a means to transport and store H2S.

Keywords

Human Neutrophil Neutrophil Apoptosis Spontaneous Apoptosis Sodium Hydrosulfide Preincubation Step 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

GSH

Glutathione

HTAU

Hypotaurine

TTAU

Thiotaurine

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Elisabetta Capuozzo
    • 1
  • Laura Pecci
    • 1
  • Alessia Baseggio Conrado
    • 1
  • Mario Fontana
    • 1
    Email author
  1. 1.Dipartimento di Scienze BiochimicheSapienza Università di RomaRomeItaly

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