Skip to main content
SpringerLink
Log in

Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats

  • Conference paper
  • First Online:
Book cover Taurine 8

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 775))

Abstract

Perinatal taurine excess or deficiency influences adult health and disease, especially relative to the autonomic nervous system. This study tests the hypothesis that perinatal taurine exposure influences adult autonomic nervous system control of arterial pressure in response to acute electrical tooth pulp stimulation. Female Sprague–Dawley rats were fed with normal rat chow with 3% β-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS), or water alone (control, C) from conception to weaning. Their male offspring were fed with normal rat chow and tap water throughout the experiment. At 8–10 weeks of age, blood chemistry, arterial pressure, heart rate, and renal sympathetic nerve activity were measured in anesthetized rats. Age, body weight, mean arterial pressure, heart rate, plasma electrolytes, blood urea nitrogen, plasma creatinine, and plasma cortisol were not significantly different among the three groups. Before tooth pulp stimulation, low- (0.3–0.5 Hz) and high-frequency (0.5–4.0 Hz) power spectral densities of arterial pressure were not significantly different among groups while the power spectral densities of renal sympathetic nerve activity were significantly decreased in TD compared to control rats. Tooth pulp stimulation did not change arterial pressure, heart rate, renal sympathetic nerve, and arterial pressure power spectral densities in the 0.3–4.0 Hz spectrum or renal sympathetic nerve firing rate in any group. In contrast, perinatal taurine imbalance disturbed very-low-frequency power spectral densities of both arterial pressure and renal sympathetic nerve activity (below 0.1 Hz), both before and after the tooth pulp stimulation. The power densities of TS were most sensitive to ganglionic blockade and central adrenergic inhibition, while those of TD were sensitive to both central and peripheral adrenergic inhibition. The present data indicate that perinatal taurine imbalance can lead to aberrant autonomic nervous system responses in adult male rats.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

AP:

Arterial pressure

C:

Control

ETPS:

Electrical tooth pulp stimulation

HR:

Heart rate

HF:

High frequency

LF:

Low frequency

MAP:

Mean arterial pressure

RA:

Renal sympathetic nerve activity

SD:

Sprague–Dawley

TD:

Taurine depletion

TS:

Taurine supplementation

References

  • Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281–286

    Article  PubMed  CAS  Google Scholar 

  • Allen GV, Pronych SP (1997) Trigeminal autonomic pathways involved in nociception-induced reflex cardiovascular responses. Brain Res 754:269–278

    Article  PubMed  CAS  Google Scholar 

  • Andrew D, Matthews B (2002) Properties of single nerve fibres that evoke blood flow changes in cat dental pulp. J Physiol 542:921–928

    Article  PubMed  CAS  Google Scholar 

  • Brotman DJ, Golden SH, Wittstein IS (2007) The cardiovascular toll of stress. Lancet 370: 1089–1100

    Article  PubMed  Google Scholar 

  • DiBona GF (2005a) Dynamic analysis of patterns of renal sympathetic nerve activity: implications for renal function. Exp Physiol 90:159–161

    Article  PubMed  Google Scholar 

  • DiBona GF (2005b) Physiology in perspective: the wisdom of the body. Neural control of the kidney. Am J Physiol Regul Integr Comp Physiol 289:R633–R641

    Article  PubMed  CAS  Google Scholar 

  • DiBona GF, Sawin LL (1999) Renal hemodynamic effects of activation of specific renal sympathetic nerve fiber groups. Am J Physiol 276:R539–R549

    PubMed  CAS  Google Scholar 

  • Drummond PD (1995) Lacrimation induced by thermal stress in patients with a facial nerve lesion. Neurology 45:1112–1114

    Article  PubMed  CAS  Google Scholar 

  • Franconi F et al (2004) Taurine administration during lactation modifies hippocampal CA1 neurotransmission and behavioural programming in adult male mice. Brain Res Bull 63:491–497

    Article  PubMed  CAS  Google Scholar 

  • Furlan R, Piazza S, Dell’Orto S, Gentile E, Cerutti S, Pagani M, Malliani A (1993) Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate. Cardiovasc Res 27:482–488

    Article  PubMed  CAS  Google Scholar 

  • Godfrey KM, Barker DJ (2001) Fetal programming and adult health. Public Health Nutr 4: 611–624

    Article  PubMed  CAS  Google Scholar 

  • Guyenet PG, Schreihofer AM, Stornetta RL (2001) Regulation of sympathetic tone and arterial pressure by the rostral ventrolateral medulla after depletion of C1 cells in rats. Ann N Y Acad Sci 940:259–269

    Article  PubMed  CAS  Google Scholar 

  • Hanson MA, Gluckman PD (2008) Developmental origins of health and disease: new insights. Basic Clin Pharmacol Toxicol 102:90–93

    Article  PubMed  CAS  Google Scholar 

  • Kemppainen P, Forster C, Handwerker HO (2001) The importance of stimulus site and intensity in differences of pain-induced vascular reflexes in human orofacial regions. Pain 91:331–338

    Article  PubMed  CAS  Google Scholar 

  • Madden CJ, Sved AF (2003) Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol Neurobiol 23:739–749

    Article  PubMed  Google Scholar 

  • Malliani A, Lombardi F, Pagani M (1994) Power spectrum analysis of heart rate variability: a tool to explore neural regulatory mechanisms. Br Heart J 71:1–2

    Article  PubMed  CAS  Google Scholar 

  • Montebugnoli L, Servidio D, Miaton RA, Prati C (2004) Heart rate variability: a sensitive parameter for detecting abnormal cardiocirculatory changes during a stressful dental procedure. J Am Dent Assoc 135:1718–1723

    PubMed  Google Scholar 

  • Mozaffari MS, Roysommuti S, Wyss JM (1996) Contribution of the sympathetic nervous system to hypertensive response to insulin excess in spontaneously hypertensive rats. J Cardiovasc Pharmacol 27:539–544

    PubMed  CAS  Google Scholar 

  • Ninomiya I, Irisawa A, Nisimaru N (1973) Nonuniformity of sympathetic nerve activity to the skin and kidney. Am J Physiol 224:256–264

    PubMed  CAS  Google Scholar 

  • Ninomiya I, Irisawa H (1975) Non-uniformity of the sympathetic nerve activity in response to baroreceptor inputs. Brain Res 87:313–322

    Article  PubMed  CAS  Google Scholar 

  • Pagani M et al (1984) Power spectral density of heart rate variability as an index of sympatho-vagal interaction in normal and hypertensive subjects. J Hypertens Suppl 2:S383–S385

    PubMed  CAS  Google Scholar 

  • Parati G, Saul JP, Di RM, Mancia G (1995) Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal. Hypertension 25:1276–1286

    Article  PubMed  CAS  Google Scholar 

  • Persson PB, Stauss H, Chung O, Wittmann U, Unger T (1992) Spectrum analysis of sympathetic nerve activity and blood pressure in conscious rats. Am J Physiol 263:H1348–H1355

    PubMed  CAS  Google Scholar 

  • Renno WM, Alkhalaf M, Mousa A, Kanaan RA (2008) A comparative study of excitatory and inhibitory amino acids in three different brainstem nuclei. Neurochem Res 33:150–159

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Jirakulsomchok D, Wyss JM (2009a) Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Adv Exp Med Biol 643: 123–133

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Lerdweeraphon W, Thaeomor A, Jirakulsomchok D, Wyss JM (2009b) Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol 643:135–144

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Thaewmor A, Lerdweeraphon W, Khimsuksri S, Jirakulsomchok D, Schaffer SW (2011) Perinatal taurine exposure alters neural control of arterial pressure via the renin-angiotensin system but not estrogen in rats. Amino Acids 41:S84

    Article  PubMed  CAS  Google Scholar 

  • Satoh-Kuriwada S, Sasano T, Date H, Karita K, Izumi H, Shoji N, Hashimoto K (2003) Centrally mediated reflex vasodilation in the gingiva induced by painful tooth-pulp stimulation in sympathectomized human subjects. J Periodontal Res 38:218–222

    Article  PubMed  CAS  Google Scholar 

  • Schaller B (2004) Trigeminocardiac reflex. A clinical phenomenon or a new physiological entity? J Neurol 251:658–665

    Article  PubMed  CAS  Google Scholar 

  • Sousa LO, Lindsey CJ (2009) Cardiovascular and baroreceptor functions of the paratrigeminal nucleus for pressor effects in non-anaesthetized rats. Auton Neurosci 147:27–32

    Article  PubMed  CAS  Google Scholar 

  • Suge R, Hosoe N, Furube M, Yamamoto T, Hirayama A, Hirano S, Nomura M (2007) Specific timing of taurine supplementation affects learning ability in mice. Life Sci 81:1228–1234

    Article  PubMed  CAS  Google Scholar 

  • Terada T, Hara K, Haranishi Y, Sata T (2011) Antinociceptive effect of intrathecal administration of taurine in rat models of neuropathic pain. Can J Anaesth 58:630–637

    Article  PubMed  Google Scholar 

  • Thaeomor A, Wyss JM, Jirakulsomchok D, Roysommuti S (2010) High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. J Biomed Sci 17(Suppl 1):S30

    Article  PubMed  Google Scholar 

  • Zhang S, Rattanatray L, McMillen IC, Suter CM, Morrison JL (2011) Periconceptional nutrition and the early programming of a life of obesity or adversity. Prog Biophys Mol Biol 106:307–314

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Sawita Khimsuksri, Dusit Jirakulsomchok & Sanya Roysommuti

  2. Department of Oral Biology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Sawita Khimsuksri

  3. Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    J. Michael Wyss

  4. School of Physiology, Institute of Science, Suranaree University of Technology, Nakhonratchasima, 30000, Thailand

    Atcharaporn Thaeomor

  5. Department of Oral Biology, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Jarin Paphangkorakit

Authors
  1. Sawita Khimsuksri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Michael Wyss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atcharaporn Thaeomor
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jarin Paphangkorakit
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dusit Jirakulsomchok
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sanya Roysommuti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sanya Roysommuti .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this paper

Cite this paper

Khimsuksri, S., Wyss, J.M., Thaeomor, A., Paphangkorakit, J., Jirakulsomchok, D., Roysommuti, S. (2013). Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 775. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6130-2_10

Download citation

Publish with us

Policies and ethics

Search

Navigation