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Taurine 8 pp 121-134 | Cite as

Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats

  • Sawita Khimsuksri
  • J. Michael Wyss
  • Atcharaporn Thaeomor
  • Jarin Paphangkorakit
  • Dusit Jirakulsomchok
  • Sanya RoysommutiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

Perinatal taurine excess or deficiency influences adult health and disease, especially relative to the autonomic nervous system. This study tests the hypothesis that perinatal taurine exposure influences adult autonomic nervous system control of arterial pressure in response to acute electrical tooth pulp stimulation. Female Sprague–Dawley rats were fed with normal rat chow with 3% β-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS), or water alone (control, C) from conception to weaning. Their male offspring were fed with normal rat chow and tap water throughout the experiment. At 8–10 weeks of age, blood chemistry, arterial pressure, heart rate, and renal sympathetic nerve activity were measured in anesthetized rats. Age, body weight, mean arterial pressure, heart rate, plasma electrolytes, blood urea nitrogen, plasma creatinine, and plasma cortisol were not significantly different among the three groups. Before tooth pulp stimulation, low- (0.3–0.5 Hz) and high-frequency (0.5–4.0 Hz) power spectral densities of arterial pressure were not significantly different among groups while the power spectral densities of renal sympathetic nerve activity were significantly decreased in TD compared to control rats. Tooth pulp stimulation did not change arterial pressure, heart rate, renal sympathetic nerve, and arterial pressure power spectral densities in the 0.3–4.0 Hz spectrum or renal sympathetic nerve firing rate in any group. In contrast, perinatal taurine imbalance disturbed very-low-frequency power spectral densities of both arterial pressure and renal sympathetic nerve activity (below 0.1 Hz), both before and after the tooth pulp stimulation. The power densities of TS were most sensitive to ganglionic blockade and central adrenergic inhibition, while those of TD were sensitive to both central and peripheral adrenergic inhibition. The present data indicate that perinatal taurine imbalance can lead to aberrant autonomic nervous system responses in adult male rats.

Keywords

Arterial Pressure Power Spectral Density Sympathetic Nerve Nerve Activity Renal Sympathetic Nerve Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AP

Arterial pressure

C

Control

ETPS

Electrical tooth pulp stimulation

HR

Heart rate

HF

High frequency

LF

Low frequency

MAP

Mean arterial pressure

RA

Renal sympathetic nerve activity

SD

Sprague–Dawley

TD

Taurine depletion

TS

Taurine supplementation

Notes

Acknowledgments

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sawita Khimsuksri
    • 1
    • 2
  • J. Michael Wyss
    • 3
  • Atcharaporn Thaeomor
    • 4
  • Jarin Paphangkorakit
    • 5
  • Dusit Jirakulsomchok
    • 1
  • Sanya Roysommuti
    • 1
    Email author
  1. 1.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  2. 2.Department of Oral Biology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  3. 3.Department of Cell, Developmental and Integrative Biology, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.School of Physiology, Institute of ScienceSuranaree University of TechnologyNakhonratchasimaThailand
  5. 5.Department of Oral Biology, Faculty of DentistryKhon Kaen UniversityKhon KaenThailand

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