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Taurine 8 pp 3-18 | Cite as

Neuropsychopharmacological Actions of Taurine

  • Shailesh P. BanerjeeEmail author
  • Andre Ragnauth
  • Christopher Y. Chan
  • Mervan S. Agovic
  • Vincent Sostris
  • Iman Jashanmal
  • Louis Vidal
  • Eitan Friedman
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

Taurine, an endogenous amino sulfonic acid, exhibits numerous neuropsychopharmacological activities. Previous studies in our laboratory have shown that it is an effective anti-cataleptic and neuro-protective agent. Current investigations show that acute or chronic administration of psychotropic drug cocaine may increase extracellular release of endogenous taurine which may protect against deleterious effects of the substances of abuse. Taurine administration was found to prevent cocaine-induced addiction by suppressing spontaneous locomotor activity and conditioned place preference. Taurine markedly delayed tail-flick response in rats which was significantly different from that in the group of animal receiving the same volume of saline, thereby indicating that taurine is a potentially valuable analgesic agent. Both taurine and endomorphin-1 were found to suppress the delayed broad negative evoked field potentials in anterior insular cortex (upper layer 5) by partially inhibiting NMDA receptor system. Thus, taurine is a unique psychopharmacological compound with potential for a variety of therapeutic uses including as a neuro-protective, anti-cataleptic, anti-addicting, and analgesic agent.

Keywords

NMDA Receptor Conditioned Place Preference NMDA Receptor Antagonist Chronic Cocaine Psychomotor Stimulant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

NMDA

N-Methyl-d-aspartate

GABA

Gama-amino-butyric acid

APV

DL-2-Amino-5-phosphonopentanoic acid

CPP

Conditioned place preference

Notes

Acknowledgments

This work was supported by DAO18055 grant from NIDA and by PSC-CUNY 41-582 grant.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Shailesh P. Banerjee
    • 1
    • 2
    Email author
  • Andre Ragnauth
    • 1
    • 3
  • Christopher Y. Chan
    • 1
    • 2
  • Mervan S. Agovic
    • 1
    • 2
    • 4
  • Vincent Sostris
    • 1
    • 2
  • Iman Jashanmal
    • 1
    • 3
  • Louis Vidal
    • 1
  • Eitan Friedman
    • 1
    • 2
  1. 1.Department of Physiology, Pharmacology and NeuroscienceSophie Davis School of Biomedical Education at CCNY, City University of New YorkNew YorkUSA
  2. 2.Neuroscience Subprogram, Doctoral Programs in BiologyGraduate Center of the City University of New YorkNew YorkUSA
  3. 3.Neuroscience Subprogram, Doctoral Programs in PsychologyGraduate Center of the City University of New YorkNew YorkUSA
  4. 4.Department of BiologyBronx Community College, The City University of New YorkNew YorkUSA

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