Skip to main content

Acute Mesenteric Ischemia

  • Chapter
  • First Online:
  • 2813 Accesses

Abstract

Acute mesenteric ischemia (AMI) is an uncommon yet life-threatening syndrome with a grave prognosis. Despite advancements in readily available diagnostics and improvements in the ability to care for critically ill patients, patients presenting with AMI face a mortality rate approaching 65 % [1–3]. This high predicted mortality has remained relatively unchanged over the past several decades even in the era of evolving endovascular approaches to management of AMI. While the reasons for this stubborn trend are likely multifactorial, failure of physicians to quickly recognize symptoms of AMI on presentation most likely drives these devastating outcomes. Once the diagnosis of AMI is entertained, prompt diagnostic studies and swift therapeutic interventions are essential to successful treatment. With any delay in intervention, AMI leads to bowel necrosis, inciting a cascade of both local organ injury and remote organ system dysfunction, which is most often irreversible and fatal.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Lock G. Acute intestinal ischaemia. Best Pract Res Clin Gastroenterol. 2001;15(1):83–98.

    Article  PubMed  CAS  Google Scholar 

  2. Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med. 2004;164(10):1054–62.

    Article  PubMed  Google Scholar 

  3. Cho JS, Carr JA, Jacobsen G, Shepard AD, Nypaver TJ, Reddy DJ. Long-term outcome after mesenteric artery reconstruction: a 37-year experience. J Vasc Surg. 2002;35(3):453–60.

    Article  PubMed  Google Scholar 

  4. Acosta S. Epidemiology of mesenteric vascular disease: clinical implications. Semin Vasc Surg. 2010;23(1):4–8.

    Article  PubMed  Google Scholar 

  5. Mamode N, Pickford I, Leiberman P. Failure to improve outcome in acute mesenteric ischaemia: seven-year review. Eur J Surg. 1999;165(3):203–8.

    Article  PubMed  CAS  Google Scholar 

  6. Sachs SM, Morton JH, Schwartz SI. Acute mesenteric ischemia. Surgery. 1982;92(4):646–53.

    PubMed  CAS  Google Scholar 

  7. Park WM, Gloviczki P, Cherry Jr KJ, Hallett Jr JW, Bower TC, Panneton JM, et al. Contemporary management of acute mesenteric ischemia: factors associated with survival. J Vasc Surg. 2002;35(3):445–52.

    Article  PubMed  Google Scholar 

  8. Morasch MD, Ebaugh JL, Chiou AC, Matsumura JS, Pearce WH, Yao JS. Mesenteric venous thrombosis: a changing clinical entity. J Vasc Surg. 2001;34(4):680–4.

    Article  PubMed  CAS  Google Scholar 

  9. Acosta-Merida MA, Marchena-Gomez J, Hemmersbach-Miller M, Roque-Castellano C, Hernandez-Romero JM. Identification of risk factors for perioperative mortality in acute mesenteric ischemia. World J Surg. 2006;30(8):1579–85.

    Article  PubMed  Google Scholar 

  10. Eltarawy IG, Etman YM, Zenati M, Simmons RL, Rosengart MR. Acute mesenteric ischemia: the importance of early surgical consultation. Am Surg. 2009;75(3):212–9.

    PubMed  Google Scholar 

  11. Akyildiz H, Akcan A, Ozturk A, Sozuer E, Kucuk C, Karahan I. The correlation of the D-dimer test and biphasic computed tomography with mesenteric computed tomography angiography in the diagnosis of acute mesenteric ischemia. Am J Surg. 2009;197(4):429–33.

    Article  PubMed  Google Scholar 

  12. Ritz JP, Runkel N, Berger G, Buhr HJ. Prognostic factors in mesenteric infarct. Zentralbl Chir. 1997;122(5):332–8.

    PubMed  CAS  Google Scholar 

  13. Nelson AL, Millington TM, Sahani D, Chung RT, Bauer C, Hertl M, et al. Hepatic portal venous gas: the ABCs of management. Arch Surg. 2009;144(6):575–81. discussion 81.

    Article  PubMed  Google Scholar 

  14. Wyers MC. Acute mesenteric ischemia: diagnostic approach and surgical treatment. Semin Vasc Surg. 2010;23(1):9–20.

    Article  PubMed  Google Scholar 

  15. Cikrit DF, Harris VJ, Hemmer CG, Kopecky KK, Dalsing MC, Hyre CE, et al. Comparison of spiral CT scan and arteriography for evaluation of renal and visceral arteries. Ann Vasc Surg. 1996;10(2):109–16.

    Article  PubMed  CAS  Google Scholar 

  16. Ofer A, Abadi S, Nitecki S, Karram T, Kogan I, Leiderman M, et al. Multidetector CT angiography in the evaluation of acute mesenteric ischemia. Eur Radiol. 2009;19(1):24–30.

    Article  PubMed  Google Scholar 

  17. Aschoff AJ, Stuber G, Becker BW, Hoffmann MH, Schmitz BL, Schelzig H, et al. Evaluation of acute mesenteric ischemia: accuracy of biphasic mesenteric multi-detector CT angiography. Abdom Imaging. 2009;34(3):345–57.

    Article  PubMed  CAS  Google Scholar 

  18. Kaleya RN, Sammartano RJ, Boley SJ. Aggressive approach to acute mesenteric ischemia. Surg Clin North Am. 1992;72(1):157–82.

    PubMed  CAS  Google Scholar 

  19. Rhee RY, Gloviczki P, Mendonca CT, Petterson TM, Serry RD, Sarr MG, et al. Mesenteric venous thrombosis: still a lethal disease in the 1990s. J Vasc Surg. 1994;20(5):688–97.

    Article  PubMed  CAS  Google Scholar 

  20. Ernst O, Asnar V, Sergent G, Lederman E, Nicol L, Paris JC, et al. Comparing contrast-enhanced breath-hold MR angiography and conventional angiography in the evaluation of mesenteric circulation. AJR Am J Roentgenol. 2000;174(2):433–9.

    Article  PubMed  CAS  Google Scholar 

  21. Demirpolat G, Oran I, Tamsel S, Parildar M, Memis A. Acute mesenteric ischemia: endovascular therapy. Abdom Imaging. 2007;32(3):299–303.

    Article  PubMed  Google Scholar 

  22. Wyers MC, Powell RJ, Nolan BW, Cronenwett JL. Retrograde mesenteric stenting during laparotomy for acute occlusive mesenteric ischemia. J Vasc Surg. 2007;45(2):269–75.

    Article  PubMed  Google Scholar 

  23. Sommer CM, Radeleff BA. A novel approach for percutaneous treatment of massive nonocclusive mesenteric ischemia: tolazoline and glycerol trinitrate as effective local vasodilators. Catheter Cardiovasc Interv. 2009;73(2):152–5.

    Article  PubMed  Google Scholar 

  24. Kaplan JL, Weintraub SL, Hunt JP, Gonzalez A, Lopera J, Brazzini A. Treatment of superior mesenteric and portal vein thrombosis with direct thrombolytic infusion via an operatively placed mesenteric catheter. Am Surg. 2004;70(7):600–4.

    PubMed  Google Scholar 

  25. Yanar H, Taviloglu K, Ertekin C, Ozcinar B, Yanar F, Guloglu R, et al. Planned second-look laparoscopy in the management of acute mesenteric ischemia. World J Gastroenterol. 2007;13(24):3350–3.

    PubMed  Google Scholar 

  26. Meng X, Liu L, Jiang H. Indications and procedures for second-look surgery in acute mesenteric ischemia. Surg Today. 2010;40(8):700–5.

    Article  PubMed  Google Scholar 

  27. Anadol AZ, Ersoy E, Taneri F, Tekin EH. Laparoscopic “second-look” in the management of mesenteric ischemia. Surg Laparosc Endosc Percutan Tech. 2004;14(4):191–3.

    Article  PubMed  Google Scholar 

  28. Ibukuro K, Tsukiyama T, Mori K, Inoue Y. The congenital anastomoses between hepatic arteries: angiographic appearance. Surg Radiol Anat. 2000;22(1):41–5.

    Article  PubMed  CAS  Google Scholar 

  29. Reuter SR, Redman HC. Gastrointestinal angiography. 2nd ed. Philadelphia, PA: WB Saunders; 1971.

    Google Scholar 

  30. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock. 2001;15(1):1–10.

    Article  PubMed  CAS  Google Scholar 

  31. Hassoun HT, Weisbrodt NW, Mercer DW, Kozar RA, Moody FG, Moore FA. Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res. 2001;97(2):150–4.

    Article  PubMed  CAS  Google Scholar 

  32. Panes J, Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology. 1998;114(5):1066–90.

    Article  PubMed  CAS  Google Scholar 

  33. Sonnino RE, Pigatt L, Schrama A, Burchett S, Franson R. Phospholipase A2 secretion during intestinal graft ischemia. Dig Dis Sci. 1997;42(5):972–81.

    Article  PubMed  CAS  Google Scholar 

  34. Tamion F, Richard V, Lyoumi S, Daveau M, Bonmarchand G, Leroy J, et al. Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock. Am J Physiol. 1997;273(2 Pt 1):G314–G21.

    PubMed  CAS  Google Scholar 

  35. Turnage RH, Kadesky KM, Bartula L, Guice KS, Oldham KT, Myers SI. Splanchnic PGI2 release and “no reflow” following intestinal reperfusion. J Surg Res. 1995;58(6):558–64.

    Article  PubMed  CAS  Google Scholar 

  36. Welborn 3rd MB, Douglas WG, Abouhamze Z, Auffenburg T, Abouhamze AS, Baumhofer J, et al. Visceral ischemia-reperfusion injury promotes tumor necrosis factor (TNF) and interleukin-1 (IL-1) dependent organ injury in the mouse. Shock. 1996;6(3):171–6.

    Article  PubMed  Google Scholar 

  37. Huber TS, Gaines GC, Welborn 3rd MB, Rosenberg JJ, Seeger JM, Moldawer LL. Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm. Shock. 2000;13(6):425–34.

    Article  PubMed  CAS  Google Scholar 

  38. Hassoun HT, Miller 3rd CC, Huynh TT, Estrera AL, Smith JJ, Safi HJ. Cold visceral perfusion improves early survival in patients with acute renal failure after thoracoabdominal aortic aneurysm repair. J Vasc Surg. 2004;39(3):506–12.

    Article  PubMed  Google Scholar 

  39. Santora RJ, Lie ML, Grigoryev DN, Nasir O, Moore FA, Hassoun HT. Therapeutic distant organ effects of regional hypothermia during mesenteric ischemia-reperfusion injury. J Vasc Surg. 2010;52(4):1003–14.

    Article  PubMed  Google Scholar 

  40. Edwards MS, Cherr GS, Craven TE, Olsen AW, Plonk GW, Geary RL, et al. Acute occlusive mesenteric ischemia: surgical management and outcomes. Ann Vasc Surg. 2003;17(1):72–9.

    Article  PubMed  Google Scholar 

  41. Klempnauer J, Grothues F, Bektas H, Pichlmayr R. Long-term results after surgery for acute mesenteric ischemia. Surgery. 1997;121(3):239–43.

    Article  PubMed  CAS  Google Scholar 

  42. Gupta PK, Natarajan B, Gupta H, Fang X, Fitzgibbons Jr RJ. Morbidity and mortality after bowel resection for acute mesenteric ischemia. Surgery. 2011;150(4):779–87.

    Article  PubMed  Google Scholar 

  43. Schermerhorn ML, Giles KA, Hamdan AD, Wyers MC, Pomposelli FB. Mesenteric revascularization: management and outcomes in the United States, 1988–2006. J Vasc Surg. 2009;50(2):341.el–8.

    Article  Google Scholar 

  44. Schoots IG, Koffeman GI, Legemate DA, Levi M, van Gulik TM. Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. Br J Surg. 2004;91(1):17–27.

    Article  PubMed  CAS  Google Scholar 

  45. Ryer EJ, Oderich GS, Bower TC, Macedo TA, Vrtiska TJ, Duncan AA, et al. Differences in anatomy and outcomes in patients treated with open mesenteric revascularization before and after the endovascular era. J Vasc Surg. 2011;53(6):1611.e2–8.

    Article  Google Scholar 

  46. Tallarita T, Oderich GS, Macedo TA, Gloviczki P, Misra S, Duncan AA, et al. Reinterventions for stent restenosis in patients treated for atherosclerotic mesenteric artery disease. J Vasc Surg. 2011;54(5): 1422.e1–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Heitham T. Hassoun M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

White, L.E., Hassoun, H.T. (2013). Acute Mesenteric Ischemia. In: Moore, L., Turner, K., Todd, S. (eds) Common Problems in Acute Care Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6123-4_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6123-4_27

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6122-7

  • Online ISBN: 978-1-4614-6123-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics