Abstract
Gastric outlet obstruction (GOO) indicates obstruction of the distal stomach, pylorus, or proximal duodenum. The term is also used to encompass lesions in the second through fourth portion of the duodenum as the demarcation between gastric outlet obstruction and duodenal obstruction is inconsistent [1]. GOO can be the result of benign or malignant conditions. While classically GOO was ascribed to noncancerous pathology, a frequently cited review by Johnson et al. of 261 patients with GOO indicated that the epidemiology of GOO is changing [2]. They noted that between 1962 and 1975, malignancy accounted for 33 % of GOO cases at their hospital in the United Kingdom. Between 1976 and 1985 malignancy accounted for 50 % of cases. However, from 1987 to 1988 malignancy was responsible for 66 % of cases of GOO. Current thinking is that GOO in adults is secondary to malignancy unless proven otherwise.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Kim ID, Kang DH, Choi CW, et al. Prevention of covered enteral stent migration in patients with malignant gastric outlet obstruction: a pilot study of anchoring with endoscopic clips. Scand J Gastroenterol. 2010;45(1):100–5.
Johnson CD, Ellis H. Gastric outlet obstruction now predicts malignancy. Br J Surg. 1990;77(9):1023–4.
Mäkelä JT, Kiviniemi H, Laitinen S. Gastric outlet obstruction caused by peptic ulcer disease analysis of 99 patients. Hepatogastroenterology. 1996;43(9):547–52.
Gibson JB, Behrman SW, Fabian TC, Britt LG. Gastric outlet obstruction resulting from peptic ulcer disease requiring surgical intervention is infrequently associated with Helicobacter pylori infection. J Am Coll Surg. 2000;191(1):32–7.
Barksdale AR, Schwartz RW. The evolving management of gastric outlet obstruction from peptic ulcer disease. Curr Surg. 2002;59(4):404–9.
Millat B, Fingerhut A, Borie F. Surgical treatment of complicated duodenal ulcers: controlled trials. World J Surg. 2000;24(3):299–306.
Piñero Madrona A, Robles R, López J, et al. Evolution of the need for operation for peptic pyloric stenosis over a period of 24 years (1976–1999). Eur J Surg. 2001;167(10):758–60.
Shabbir J, Durrani S, Ridgway PF, Mealy K. Proton pump inhibition is a feasible primary alternative to surgery and balloon dilatation in adult peptic pyloric stenosis (APS): report of six consecutive cases. Ann R Coll Surg Engl. 2006;88(2):174–5.
Ferzoco S, Soybel D. Gastric outlet obstruction, peforation, and other complications of gastroduodenal ulcer. In: Wolfe M, editor. Therapy of digestive disorders. 2nd ed. Philadelphia, PA: Saunders; 2006. p. 357–72.
Berg D, Dempsey DT. Peptic ulcer disease: obstruction. In: Bland K, editor. General surgery principles and international practice. New York: Springer; 2009. p. 525–32.
Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005;140(2):201–8.
Richard K. Gastrointestinal dilation. In: Yamada T, Alpers D, Owyang C, editors. Textbook of gastroenterology. Philadelphia: Lippincott; 1990. p. 2039–54.
Helmer K, Mercer D. Gastric physiology and acid-peptic disorders. In: Miller T, editor. Modern surgical care. 3rd ed. New York: Informa; 2006. p. 333–67.
Adler DG. Enteral stents for malignant gastric outlet obstruction: testing our mettle. Gastrointest Endosc. 2007;66(2):361–3.
Mohammed AA, Benmousa A, Almeghaiseeb I, Alkarawi M. Gastric outlet obstruction. Hepatogastroenterology. 2007;54(80):2415–20.
Ellis H. Pyloric stenosis complicating duodenal ulceration. World J Surg. 1987;11(3):315–8.
Gaughan C, Dempsey DT. Management of duodenal ulcer. In: Cameron J, Cameron A, editors. Current surgical therapy. 10th ed. Philadelphia, PA: Elsevier Saunders; 2011. p. 68–73.
Mabogunje OA, Lawrie JH. Surgical management of duodenal ulcer in Zaria, Nigeria. J R Coll Surg Edinb. 1985;30(5):283–7.
Cherian PT, Cherian S, Singh P. Long-term follow-up of patients with gastric outlet obstruction related to peptic ulcer disease treated with endoscopic balloon dilatation and drug therapy. Gastrointest Endosc. 2007;66(3):491–7.
Kuwada SK, Alexander GL. Long-term outcome of endoscopic dilation of nonmalignant pyloric stenosis. Gastrointest Endosc. 1995;41(1):15–7.
Lam YH, Lau JY, Fung TM, et al. Endoscopic balloon dilation for benign gastric outlet obstruction with or without Helicobacter pylori infection. Gastrointest Endosc. 2004;60(2):229–33.
Abdel-Salam WN, Katri KM, Bessa SS, El-Kayal E-SA. Laparoscopic-assisted truncal vagotomy and gastro-jejunostomy: trial of simplification. J Laparoendosc Adv Surg Tech A. 2009;19(2):125–7.
Pollard SG, Friend PJ, Dunn DC, Hunter JO. Highly selective vagotomy with duodenal dilatation in patients with duodenal ulceration and gastric outlet obstruction. Br J Surg. 1990;77(12):1365–6.
Goldstein H, Boyle JD. The saline load test–a bedside evaluation of gastric retention. Gastroenterology. 1965;49(4):375–80.
Griffith GH, Owen GM, Kirkman S, Shields R. Measurement of rate of gastric emptying using chromium-51. Lancet. 1966;1(7449):1244–5.
Maetani I, Ukita T, Tada T, et al. Gastric emptying in patients with palliative stenting for malignant gastric outlet obstruction. Hepatogastroenterology. 2008;55(81):298–302.
Matolo NM, Stadalnik RC. Assessment of gastric motility using meal labeled with technetium-99m sulfur colloid. Am J Surg. 1983;146(6):823–6.
Yusuf TE, Brugge WR. Endoscopic therapy of benign pyloric stenosis and gastric outlet obstruction. Curr Opin Gastroenterol. 2006;22(5):570–3.
Awan A, Johnston DE, Jamal MM. Gastric outlet obstruction with benign endoscopic biopsy should be further explored for malignancy. Gastrointest Endosc. 1988;48(5):497–500.
Newman N, Mufeed S, Makary M. Benign gastric ulcer. In: Cameron J, Cameron A, editors. Current surgical therapy. 10th ed. Philadelphia, PA: Elsevier Saunders; 2011. p. 63–8.
Choudhary AM, Roberts I, Nagar A, Tabrez S, Gupta T. Helicobacter pylori-related gastric outlet obstruction: is there a role for medical treatment? J Clin Gastroenterol. 2001;32(3):272–3.
Dempsey DT. Management of benign gastric outlet obstruction in the adult patient. Curr Surg. 2002;59(2):158–62.
Kochhar R, Poornachandra KS, Dutta U, Agrawal A, Singh K. Early endoscopic balloon dilation in caustic-induced gastric injury. Gastrointest Endosc. 2010;71(4):737–44.
Boylan JJ, Gradzka MI. Long-term results of endoscopic balloon dilatation for gastric outlet obstruction. Dig Dis Sci. 1999;44(9):1883–6.
Kovacs T, Jensen D. Complications of peptic ulcer disease. In: DiMarino A, Benjamin SB, editors. Gastrointestinal disease: an endoscopic approach. 2nd ed. Thorofare, NJ: Slack; 2002. p. 411–38.
Artifon ELA, Sakai P, Hondo FY, et al. An evaluation of gastric scintigraphy pre- and postpyloroduodenal peptic stenosis dilation. Surg Endosc. 2006;20(2):243–8.
Harrell AG, Sing RF, Novitsky YW, et al. A re-evaluation of vagotomy and gastrojejunostomy for benign gastric outlet obstruction. J Laparoendosc Adv Surg Tech A. 2006;16(1):77–8. author reply 78.
Broderick T, Matthews J. Ulcer complications. In: Zinner M, Ashley S, editors. Maingot’s abdominal operations. 11th ed. New York: McGraw-Hill Medical; 2007. p. 353–77.
Siu WT, Tang CN, Law BKB, et al. Vagotomy and gastrojejunostomy for benign gastric outlet obstruction. J Laparoendosc Adv Surg Tech A. 2004;14(5):266–9.
Csendes A, Burgos AM, Smok G, et al. Latest results (12–21 years) of a prospective randomized study comparing Billroth II and Roux-en-Y anastomosis after a partial gastrectomy plus vagotomy in patients with duodenal ulcers. Ann Surg. 2009;249(2):189–94.
Csendes A, Maluenda F, Braghetto I, et al. Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. Am J Surg. 1993;166(1):45–9.
Kim S-M, Song J, Oh SJ, et al. Comparison of laparoscopic truncal vagotomy with gastrojejunostomy and open surgery in peptic pyloric stenosis. Surg Endosc. 2009;23(6):1326–30.
Wyman A, Stuart RC, Ng EK, Chung SC, Li AK. Laparoscopic truncal vagotomy and gastroenterostomy for pyloric stenosis. Am J Surg. 1996;171(6):600–3.
Saccomani GE, Percivale A, Stella M, Durante V, Pellicci R. Laparoscopic billroth II gastrectomy for completely stricturing duodenal ulcer: technical details. Scand J Surg. 2003;92(3):200–2.
Rangarajan M, Subramanian CS, Chandralathan TA. Laparoscopy-assisted truncal vagotomy with antecolic posterior gastrojejunostomy for benign gastric outlet obstruction. Surg Endosc. 2006;20(1):61–3.
Kelly K, Teotia S. Proximal gastric vagotomy. In: Fischer J, editor. Mastery of surgery. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2007. p. 872–7.
Mills GH, Jones RB. Explosion during surgery for gastric outlet obstruction. Anaesthesia. 1993;48(6):544.
Søreide K, Sarr MG, Søreide JA. Pyloroplasty for benign gastric outlet obstruction–indications and techniques. Scand J Surg. 2006;95(1):11–6.
Maull KI, Price DC. Migratory gallstone causing duodenal obstruction. J Am Coll Surg. 2006;203(5):781.
Rodriguez Romano D, Moreno Gonzalez E, Jiménez Romero C, et al. Duodenal obstruction by gallstones (Bouveret’s syndrome). Presentation of a new case and literature review. Hepatogastroenterology. 1997;44(17):1351–5.
Yamamoto T, Allan RN, Keighley MR. An audit of gastroduodenal Crohn disease: clinicopathologic features and management. Scand J Gastroenterol. 1999;34(10):1019–24.
Go MR, Muscarella 2nd P, Needleman BJ, Cook CH, Melvin WS. Endoscopic management of stomal stenosis after Roux-en-Y gastric bypass. Surg Endosc. 2004;18(1):56–9.
Vance PL, de Lange EE, Shaffer Jr HA, Schirmer B. Gastric outlet obstruction following surgery for morbid obesity: efficacy of fluoroscopically guided balloon dilation. Radiology. 2002;222(1):70–2.
Peifer KJ, Shiels AJ, Azar R, et al. Successful endoscopic management of gastrojejunal anastomotic strictures after Roux-en-Y gastric bypass. Gastrointest Endosc. 2007;66(2):248–52.
Ahmad J, Martin J, Ikramuddin S, Schauer P, Slivka A. Endoscopic balloon dilation of gastroenteric anastomotic stricture after laparoscopic gastric bypass. Endoscopy. 2003;35(9):725–8.
Rao YG, Pande GK, Sahni P, Chattopadhyay TK. Gastroduodenal tuberculosis management guidelines, based on a large experience and a review of the literature. Can J Surg. 2004;47(5):364–8.
Yau KK, Siu WT, Cheung HYS, Yang GPC, Li MK. Acute gastric volvulus: an unusual cause of gastric outlet obstruction. Minim Invasive Ther Allied Technol. 2005;14(1):2–5.
Deitch JS, Heller JA, McGagh D, et al. Abdominal aortic aneurysm causing duodenal obstruction: two case reports and review of the literature. J Vasc Surg. 2004;40(3):543–7.
O’Carroll R, Kennedy R. Gastric outlet obstruction. Can J Surg. 2007;50(6):E29–30.
Kochhar R, Dutta U, Sethy PK, et al. Endoscopic balloon dilation in caustic-induced chronic gastric outlet obstruction. Gastrointest Endosc. 2009;69(4):800–5.
Savas J, Miller T, Mercer D. Derangements in gastrointestinal function secondary to previous surgery. In: Miller T, editor. Modern surgical care: physiologic foundations and clinical applications. 3rd ed. New York: Informa Healthcare; 2006.
Madriaga M, Soybel D. Motility disorders of the stomach and small bowel. In: Cameron J, Cameron A, editors. Current surgical therapy. 10th ed. Philadelphia, PA: Elsevier Saunders; 2011. p. 117–24.
Shone DN, Nikoomanesh P, Smith-Meek MM, Bender JS. Malignancy is the most common cause of gastric outlet obstruction in the era of H2 blockers. Am J Gastroenterol. 1995;90(10):1769–70.
Khullar SK, DiSario JA. Gastric outlet obstruction. Gastrointest Endosc Clin N Am. 1996;6(3):585–603.
Misra SP, Dwivedi M, Misra V. Malignancy is the most common cause of gastric outlet obstruction even in a developing country. Endoscopy. 1998;30(5):484–6.
Al-Rashedy M, Dadibhai M, Shareif A, et al. Laparoscopic gastric bypass for gastric outlet obstruction is associated with smoother, faster recovery and shorter hospital stay compared with open surgery. J Hepatobiliary Pancreat Surg. 2005;12(6):474–8.
Adler DG, Baron TH. Endoscopic palliation of malignant gastric outlet obstruction using self-expanding metal stents: experience in 36 patients. Am J Gastroenterol. 2002;97(1):72–8.
Lillemoe KD, Cameron JL, Hardacre JM, et al. Is prophylactic gastrojejunostomy indicated for unresectable periampullary cancer? A prospective randomized trial. Ann Surg. 1999;230(3):322–8. discussion 328–330.
Choi Y-B. Laparoscopic gatrojejunostomy for palliation of gastric outlet obstruction in unresectable gastric cancer. Surg Endosc. 2002;16(11):1620–6.
Del Piano M, Ballarè M, Montino F, et al. Endoscopy or surgery for malignant GI outlet obstruction? Gastrointest Endosc. 2005;61(3):421–6.
Medina-Franco H, Abarca-Pérez L, España-Gómez N, et al. Morbidity-associated factors after gastrojejunostomy for malignant gastric outlet obstruction. Am Surg. 2007;73(9):871–5.
Bergamaschi R, Arnaud JP, Mårvik R, Myrvold HE. Laparoscopic antiperistaltic versus isoperistaltic gastrojejunostomy for palliation of gastric outlet obstruction in advanced cancer. Surg Laparosc Endosc Percutan Tech. 2002;12(6):393–7.
House MG, Choti MA. Palliative therapy for pancreatic/biliary cancer. Surg Clin North Am. 2005;85(2):359–71.
Maetani I, Isayama H, Mizumoto Y. Palliation in patients with malignant gastric outlet obstruction with a newly designed enteral stent: a multicenter study. Gastrointest Endosc. 2007;66(2):355–60.
Hosono S, Ohtani H, Arimoto Y, Kanamiya Y. Endoscopic stenting versus surgical gastroenterostomy for palliation of malignant gastroduodenal obstruction: a meta-analysis. J Gastroenterol. 2007;42(4):283–90.
Siddiqui A, Spechler SJ, Huerta S. Surgical bypass versus endoscopic stenting for malignant gastroduodenal obstruction: a decision analysis. Dig Dis Sci. 2007;52(1):276–81.
Piesman M, Kozarek RA, Brandabur JJ, et al. Improved oral intake after palliative duodenal stenting for malignant obstruction: a prospective multicenter clinical trial. Am J Gastroenterol. 2009;104(10):2404–11.
Song H-Y, Shin JH, Yoon CJ, et al. A dual expandable nitinol stent: experience in 102 patients with malignant gastroduodenal strictures. J Vasc Interv Radiol. 2004;15(12):1443–9.
Lowe AS, Beckett CG, Jowett S, et al. Self-expandable metal stent placement for the palliation of malignant gastroduodenal obstruction: experience in a large, single, UK centre. Clin Radiol. 2007;62(8):738–44.
Larssen L, Medhus AW, Hauge T. Treatment of malignant gastric outlet obstruction with stents: an evaluation of the reported variables for clinical outcome. BMC Gastroenterol. 2009;9:45.
Watanabe A, Maehara Y, Okuyama T, et al. Gastric carcinoma with pyloric stenosis. Surgery. 1998;123(3):330–4.
Schmidt C, Gerdes H, Hawkins W, et al. A prospective observational study examining quality of life in patients with malignant gastric outlet obstruction. Am J Surg. 2009;198(1):92–9.
Maetani I, Akatsuka S, Ikeda M, et al. Self-expandable metallic stent placement for palliation in gastric outlet obstructions caused by gastric cancer: a comparison with surgical gastrojejunostomy. J Gastroenterol. 2005;40(10):932–7.
Gaidos JKJ, Draganov PV. Treatment of malignant gastric outlet obstruction with endoscopically placed self-expandable metal stents. World J Gastroenterol. 2009;15(35):4365–71.
Baron TH, Harewood GC. Enteral self-expandable stents. Gastrointest Endosc. 2003;58(3):421–33.
Kim CG, Choi IJ, Lee JY, et al. Covered versus uncovered self-expandable metallic stents for palliation of malignant pyloric obstruction in gastric cancer patients: a randomized, prospective study. Gastrointest Endosc. 2010;72(1):25–32.
Jeurnink SM, van Eijck CHJ, Steyerberg EW, Kuipers EJ, Siersema PD. Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review. BMC Gastroenterol. 2007;7:18.
Singer SB, Asch M. Metallic stents in the treatment of duodenal obstruction: technical issues and results. Can Assoc Radiol J. 2000;51(2):121–9.
Aviv RI, Shyamalan G, Khan FH, et al. Use of stents in the palliative treatment of malignant gastric outlet and duodenal obstruction. Clin Radiol. 2002;57(7):587–92.
Shaw JM, Bornman PC, Krige JEJ, Stupart DA, Panieri E. Self-expanding metal stents as an alternative to surgical bypass for malignant gastric outlet obstruction. Br J Surg. 2010;97(6):872–6.
Cho YK, Kim SW, Hur WH, et al. Clinical outcomes of self-expandable metal stent and prognostic factors for stent patency in gastric outlet obstruction caused by gastric cancer. Dig Dis Sci. 2010;55(3):668–74.
Dormann A, Meisner S, Verin N, Wenk Lang A. Self-expanding metal stents for gastroduodenal malignancies: systematic review of their clinical effectiveness. Endoscopy. 2004;36(6):543–50.
Stupart DA, Panieri E, Dent DM. Gastrojejunostomy for gastric outlet obstruction in patients with gastric carcinoma. S Afr J Surg. 2006;44(2):52–4.
McFadden D, Schneider J. Gastric adenocarcinoma. In: Cameron J, Cameron A, editors. Current surgical therapy. 10th ed. Philadelphia, PA: Elsevier Saunders; 2011. p. 80–5.
Watanapa P, Williamson RC. Surgical palliation for pancreatic cancer: developments during the past two decades. Br J Surg. 1992;79(1):8–20.
Guzman EA, Dagis A, Bening L, Pigazzi A. Laparoscopic gastrojejunostomy in patients with obstruction of the gastric outlet secondary to advanced malignancies. Am Surg. 2009;75(2):129–32.
Nagy A, Brosseuk D, Hemming A, Scudamore C, Mamazza J. Laparoscopic gastroenterostomy for duodenal obstruction. Am J Surg. 1995;169(5):539–42.
Ghanem AM, Hamade AM, Sheen AJ, et al. Laparoscopic gastric and biliary bypass: a single-center cohort prospective study. J Laparoendosc Adv Surg Tech A. 2006;16(1):21–6.
Gentileschi P, Kini S, Gagner M. Palliative laparoscopic hepatico- and gastrojejunostomy for advanced pancreatic cancer. JSLS. 2002;6(4):331–8.
Kazanjian KK, Reber HA, Hines OJ. Laparoscopic gastrojejunostomy for gastric outlet obstruction in pancreatic cancer. Am Surg. 2004;70(10):910–3.
Alam TA, Baines M, Parker MC. The management of gastric outlet obstruction secondary to inoperable cancer. Surg Endosc. 2003;17(2):320–3.
Lillemoe KD, Sauter PK, Pitt HA, Yeo CJ, Cameron JL. Current status of surgical palliation of periampullary carcinoma. Surg Gynecol Obstet. 1993;176(1):1–10.
Fiori E, Lamazza A, Volpino P, et al. Palliative management of malignant antro-pyloric strictures. Gastroenterostomy versus endoscopic stenting. A randomized prospective trial. Anticancer Res. 2004;24(1):269–71.
Johnsson E, Thune A, Liedman B. Palliation of malignant gastroduodenal obstruction with open surgical bypass or endoscopic stenting: clinical outcome and health economic evaluation. World J Surg. 2004;28(8):812–7.
Espinel J, Sanz O, Vivas S, et al. Malignant gastrointestinal obstruction: endoscopic stenting versus surgical palliation. Surg Endosc. 2006;20(7):1083–7.
Jeurnink SM, Steyerberg EW, van Hooft JE, et al. Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastrointest Endosc. 2010;71(3):490–9.
Ly J, O’Grady G, Mittal A, Plank L, Windsor JA. A systematic review of methods to palliate malignant gastric outlet obstruction. Surg Endosc. 2010;24(2):290–7.
Skandalakis L, Gray S, Skandalakis J. The history and surgical anatomy of the vagus nerve. Surg Gynecol Obstet. 1986;162:83.
Diesen D, Haney J, Pappas J. Laparoscopic management of peptic ulcer disease. In: Pappas T, Pryor A, Harnisch M, editors. Atlas of laparoscopic surgery. 3rd ed. New York: Current Medicine; 2008. p. 65–79.
Brune IB, Feussner H, Neuhaus H, Classen M, Siewert JR. Laparoscopic gastrojejunostomy and endoscopic biliary stent placement for palliation of incurable gastric outlet obstruction with cholestasis. Surg Endosc. 1997;11(8):834–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jawa, R.S., Mercer, D.W. (2013). Gastric Outlet Obstruction. In: Moore, L., Turner, K., Todd, S. (eds) Common Problems in Acute Care Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6123-4_18
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6123-4_18
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6122-7
Online ISBN: 978-1-4614-6123-4
eBook Packages: MedicineMedicine (R0)