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Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health

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Book cover Sequential Experimentation in Clinical Trials

Part of the book series: Springer Series in Statistics ((SSS,volume 298))

Abstract

In this chapter we describe the applications of sequential testing methodology to the problem of testing the incidence rates of adverse events in vaccine clinical trials and post-marketing safety evaluation. Section 5.1 describes typical design considerations for vaccine safety evaluation and the application of the SPRT and its other sequential tests that have been applied to test vaccine safety.

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Authors and Affiliations

  1. Department of Mathematics, University of Southern California, Los Angeles, California, USA

    Jay Bartroff

  2. Department of Statistics and Cancer Institute, Stanford University, Stanford, California, USA

    Tze Leung Lai

  3. Department of Health Research and Policy, Stanford University VA Cooperative Studies Program, Stanford, California, USA

    Mei-Chiung Shih

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Bartroff, J., Lai, T.L., Shih, MC. (2013). Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health. In: Sequential Experimentation in Clinical Trials. Springer Series in Statistics, vol 298. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6114-2_5

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