• Jay Bartroff
  • Tze Leung Lai
  • Mei-Chiung Shih
Part of the Springer Series in Statistics book series (SSS, volume 298)


This chapter gives an overview of (a) the prevalence of sequential experimentation in translational medical research and (b) developments of statistical methods to design and analyze these sequential experiments in evidence-based medical research. In this connection it also gives an outline of the topics covered in the subsequent chapters and discusses the complementary roles of Bayesian and frequentist approaches to sequential design and analysis.


Adaptive Design Sequential Probability Ratio Test Generalize Likelihood Ratio Bandit Problem Bayesian Design 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jay Bartroff
    • 1
  • Tze Leung Lai
    • 2
  • Mei-Chiung Shih
    • 3
  1. 1.Department of MathematicsUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Statistics and Cancer InstituteStanford UniversityStanfordUSA
  3. 3.Department of Health Research and PolicyStanford University VA Cooperative Studies ProgramStanfordUSA

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