Skip to main content
SpringerLink
Log in

Perinatal Taurine Imbalance Alters the Interplay of Renin–Angiotensin System and Estrogen on Glucose–Insulin Regulation in Adult Female Rats

  • Conference paper
  • First Online:
Taurine 8

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 776))

Abstract

Perinatal taurine depletion followed by high sugar intake (postweaning) alters the renin–angiotensin system (RAS) and glucose regulation in adult female rats. This study tests the hypothesis that in adult female rats, RAS and estrogen contribute to insulin resistance resulting from perinatal taurine imbalance. Female Sprague–Dawley rats were fed normal rat chow with 3% β-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS), or water alone (control, C) from conception to weaning. Their female offspring were fed normal rat chow with 5% glucose in water (TDG, TSG, CG) or water alone (TDW, TSW, CW) throughout the experiment. At 7–8 weeks of age, animals were studied with or without captopril inhibition of the RAS and with or without estrogen receptor inhibition by tamoxifen. Compared to CW and CG groups, perinatal taurine depletion but not supplementation slightly increased plasma insulin levels. High sugar intake slightly increased plasma insulin only in TSG. Captopril treatment significantly increased plasma insulin in all groups except CG (the greatest increase was in TDG). Changes in insulin resistance and insulin secretion paralleled the changes in plasma insulin levels. In contrast, tamoxifen treatment increased insulin resistance and decreased insulin secretion only in TDG and this group displayed hyperglycemia and glucose intolerance. These data indicate that perinatal taurine imbalance alters the interplay of RAS and estrogen on glucose–insulin regulation in adult female rats.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

CW:

Control with water intake alone

CW + Cap:

CW plus captopril treatment

CW + Tam:

CW plus tamoxifen treatment

CG:

Control with high sugar intake

CG + Cap:

CG plus captopril treatment

CG + Tam:

CG plus tamoxifen treatment

TDW:

Perinatal taurine depletion with water intake alone

TDW + Cap:

TDW plus captopril treatment

TDW + Tam:

TDW plus tamoxifen treatment

TDG:

Perinatal taurine depletion with high sugar intake

TDG + Cap:

TDG plus captopril treatment

TDG + Tam:

TDG plus tamoxifen treatment

TSW:

Perinatal taurine supplementation with water intake alone

TSW + Cap:

TSW plus captopril treatment

TSW + Tam:

TSW plus tamoxifen treatment

TSG:

Perinatal taurine supplementation with high sugar intake

TSG + Cap:

TSG plus captopril treatment

TSG + Tam:

TSG plus tamoxifen treatment

RAS:

Renin–angiotensin system

SD:

Sprague–Dawley

References

  • Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281–286

    Article  PubMed  CAS  Google Scholar 

  • Arany E, Strutt B, Romanus P, Remacle C, Reusens B, Hill DJ (2004) Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia 47:1831–1837

    Article  PubMed  CAS  Google Scholar 

  • Ashraf MS, Vongpatanasin W (2006) Estrogen and hypertension. Curr Hypertens Rep 8:368–376

    Article  PubMed  CAS  Google Scholar 

  • Boujendar S, Reusens B, Merezak S, Ahn MT, Arany E, Hill D, Remacle C (2002) Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia 45:856–866

    Article  PubMed  CAS  Google Scholar 

  • Buchanan TA et al (1993) Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism. J Clin Invest 92:720–726

    Article  PubMed  CAS  Google Scholar 

  • Cheng Q, Leung PS (2011) An update on the islet renin-angiotensin system. Peptides 32:1087–1095

    Article  PubMed  CAS  Google Scholar 

  • Fliser D, Dikow R, Demukaj S, Ritz E (2000) Opposing effects of angiotensin II on muscle and renal blood flow under euglycemic conditions. J Am Soc Nephrol 11:2001–2006

    PubMed  CAS  Google Scholar 

  • Harada H, Tsujino T, Watari Y, Nonaka H, Emoto N, Yokoyama M (2004) Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels 19:132–136

    Article  PubMed  Google Scholar 

  • Hayden MR, Sowers KM, Pulakat L, Joginpally T, Krueger B, Whaley-Connell A, Sowers JR (2011) Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus. Cardiorenal Med 1:193–210

    Article  PubMed  CAS  Google Scholar 

  • Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci USA 97:12729–12734

    Article  PubMed  CAS  Google Scholar 

  • Henriksen EJ (2007) Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 293:R974–R980

    Google Scholar 

  • Hultman K, Alexanderson C, Manneras L, Sandberg M, Holmang A, Jansson T (2007) Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring. J Physiol 579:823–833

    Article  PubMed  CAS  Google Scholar 

  • Jonk AM, Houben AJ, Schaper NC, de Leeuw PW, Serne EH, Smulders YM, Stehouwer CD (2010) Angiotensin II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers. J Clin Endocrinol Metab 95:3901–3908

    Article  PubMed  CAS  Google Scholar 

  • Kim C (2012) Does menopause increase diabetes risk? Strategies for diabetes prevention in midlife women. Womens Health (Lond Engl) 8:155–167

    Article  Google Scholar 

  • Kim SJ, Gupta RC, Lee HW (2007) Taurine-diabetes interaction: from involvement to protection. Curr Diabetes Rev 3:165–175

    Article  PubMed  CAS  Google Scholar 

  • Luther JM, Brown NJ (2011) The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol Sci 32:734–739

    Article  PubMed  CAS  Google Scholar 

  • Merezak S, Hardikar AA, Yajnik CS, Remacle C, Reusens B (2001) Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurine. J Endocrinol 171:299–308

    Article  PubMed  CAS  Google Scholar 

  • Meyer MR, Clegg DJ, Prossnitz ER, Barton M (2011) Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf) 203:259–269

    Article  CAS  Google Scholar 

  • Nandhini AT, Anuradha CV (2004) Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats. Amino Acids 26:299–303

    Article  PubMed  CAS  Google Scholar 

  • Patiag D, Qu X, Gray S, Idris I, Wilkes M, Seale JP, Donnelly R (2000) Possible interactions between angiotensin II and insulin: effects on glucose and lipid metabolism in vivo and in vitro. J Endocrinol 167:525–531

    Article  PubMed  CAS  Google Scholar 

  • Rahman MM et al (2011) Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension. Am J Hypertens 24:574–581

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez R, Viscarra JA, Minas JN, Nakano D, Nishiyama A, Ortiz RM (2012) Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome. Endocrinology 153:1684–1695

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Khongnakha T, Jirakulsomchok D, Wyss JM (2002) Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance. Am J Hypertens 15:773–779

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Jirakulsomchok D, Wyss JM (2009a) Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Adv Exp Med Biol 643:123–133

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Lerdweeraphon W, Thaeomor A, Jirakulsomchok D, Wyss JM (2009b) Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol 643:135–144

    Article  PubMed  CAS  Google Scholar 

  • Suzuki K, Nakagawa O, Aizawa Y (2008) Improved early-phase insulin response after candesartan treatment in hypertensive patients with impaired glucose tolerance. Clin Exp Hypertens 30:309–314

    Article  PubMed  CAS  Google Scholar 

  • Thaeomor A, Wyss JM, Jirakulsomchok D, Roysommuti S (2010) High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. J Biomed Sci 17(Suppl 1):S30

    Article  PubMed  Google Scholar 

  • Townsend RR, DiPette DJ (1993) Pressor doses of angiotensin II increase insulin-mediated glucose uptake in normotensive men. Am J Physiol 265:E362–E366

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Sanya Roysommuti & Wichaporn Lerdweeraphon

  2. School of Physiology, Institute of Science, Suranaree University of Technology, Nakhonratchasima, 30000, Thailand

    Atcharaporn Thaeomor

  3. Department of Oral Biology, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Sawita Khimsuksri

  4. Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    J. Michael Wyss

Authors
  1. Sanya Roysommuti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atcharaporn Thaeomor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sawita Khimsuksri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wichaporn Lerdweeraphon
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Michael Wyss
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sanya Roysommuti .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this paper

Cite this paper

Roysommuti, S., Thaeomor, A., Khimsuksri, S., Lerdweeraphon, W., Wyss, J.M. (2013). Perinatal Taurine Imbalance Alters the Interplay of Renin–Angiotensin System and Estrogen on Glucose–Insulin Regulation in Adult Female Rats. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 776. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6093-0_8

Download citation

Publish with us

Policies and ethics

Search

Navigation