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Taurine 8 pp 67-80 | Cite as

Perinatal Taurine Imbalance Alters the Interplay of Renin–Angiotensin System and Estrogen on Glucose–Insulin Regulation in Adult Female Rats

  • Sanya RoysommutiEmail author
  • Atcharaporn Thaeomor
  • Sawita Khimsuksri
  • Wichaporn Lerdweeraphon
  • J. Michael Wyss
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 776)

Abstract

Perinatal taurine depletion followed by high sugar intake (postweaning) alters the renin–angiotensin system (RAS) and glucose regulation in adult female rats. This study tests the hypothesis that in adult female rats, RAS and estrogen contribute to insulin resistance resulting from perinatal taurine imbalance. Female Sprague–Dawley rats were fed normal rat chow with 3% β-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS), or water alone (control, C) from conception to weaning. Their female offspring were fed normal rat chow with 5% glucose in water (TDG, TSG, CG) or water alone (TDW, TSW, CW) throughout the experiment. At 7–8 weeks of age, animals were studied with or without captopril inhibition of the RAS and with or without estrogen receptor inhibition by tamoxifen. Compared to CW and CG groups, perinatal taurine depletion but not supplementation slightly increased plasma insulin levels. High sugar intake slightly increased plasma insulin only in TSG. Captopril treatment significantly increased plasma insulin in all groups except CG (the greatest increase was in TDG). Changes in insulin resistance and insulin secretion paralleled the changes in plasma insulin levels. In contrast, tamoxifen treatment increased insulin resistance and decreased insulin secretion only in TDG and this group displayed hyperglycemia and glucose intolerance. These data indicate that perinatal taurine imbalance alters the interplay of RAS and estrogen on glucose–insulin regulation in adult female rats.

Keywords

Insulin Resistance Glucose Intolerance Taurine Supplementation Insulin Regulation Increase Plasma Insulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CW

Control with water intake alone

CW + Cap

CW plus captopril treatment

CW + Tam

CW plus tamoxifen treatment

CG

Control with high sugar intake

CG + Cap

CG plus captopril treatment

CG + Tam

CG plus tamoxifen treatment

TDW

Perinatal taurine depletion with water intake alone

TDW + Cap

TDW plus captopril treatment

TDW + Tam

TDW plus tamoxifen treatment

TDG

Perinatal taurine depletion with high sugar intake

TDG + Cap

TDG plus captopril treatment

TDG + Tam

TDG plus tamoxifen treatment

TSW

Perinatal taurine supplementation with water intake alone

TSW + Cap

TSW plus captopril treatment

TSW + Tam

TSW plus tamoxifen treatment

TSG

Perinatal taurine supplementation with high sugar intake

TSG + Cap

TSG plus captopril treatment

TSG + Tam

TSG plus tamoxifen treatment

RAS

Renin–angiotensin system

SD

Sprague–Dawley

Notes

Acknowledgements

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sanya Roysommuti
    • 1
    Email author
  • Atcharaporn Thaeomor
    • 2
  • Sawita Khimsuksri
    • 3
  • Wichaporn Lerdweeraphon
    • 1
  • J. Michael Wyss
    • 4
  1. 1.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  2. 2.School of Physiology, Institute of ScienceSuranaree University of TechnologyNakhonratchasimaThailand
  3. 3.Department of Oral Biology, Faculty of DentistryKhon Kaen UniversityKhon KaenThailand
  4. 4.Department of Cell, Developmental and Integrative BiologySchool of Medicine, University of Alabama at BirminghamBirminghamUSA

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