Advertisement

Taurine 8 pp 51-58 | Cite as

Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats

  • Mi-Ja ChoiEmail author
  • Ji-Na Seo
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 776)

Abstract

The purpose of this study was to investigate the effect of dietary taurine supplementation on bone mineral density (BMD) and bone mineral content (BMC) in rats. Twenty Sprague–Dawley male rats (body weight 200 ± 10 g) were divided into two groups, control and taurine group (2% taurine-supplemented diet). All rats were fed on experimental diet and deionized water and libitum for 6 weeks. Serum alkaline phosphatase (ALP) activity, osteocalcin, PTH, and urinary deoxypyridinoline cross-links value were measured as markers of bone formation and resorption. BMD and BMC were measured using PIXImus (GE Lunar Co., Wisconsin) in spine and femur. The effect of diet on ALP, osteocalcine, and PTH was not significant. There were no significant differences in ALP, osteocalcine, and PTH concentration. Urinary calcium excretion was lower in taurine group than in control group. Femur BMC/weight of taurine group was significantly higher than control group. The results of this study showed the possible role of taurine in bone metabolism in male rats.

Keywords

Bone Mineral Density Bone Mineral Content Spine Bone Mineral Density Urinary Calcium Excretion Femur Bone Mineral Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ALP

Alkaline phosphatase

DPD

Deoxypyridinoline

Tau

Taurine

DPD/Cr

Creatinine excretion

BMD

Bone mineral density

BMC

Bone mineral content

FER

Food efficiency ratio

SBMD

Spine bone mineral density

SBMC

Spine bone mineral content

FBMD

Femur bone mineral density

FBMC

Femur bone mineral content

References

  1. Anuradha CV, Balakrishnan SD (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol 77:749–754PubMedCrossRefGoogle Scholar
  2. Belury MA (2002) Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr 22:505–531PubMedCrossRefGoogle Scholar
  3. Bouckenooghe T, Remacle C, Reusens B (2006) Is taurine a functional nutrient? Curr Opin Clin Nutr Metab Care 9:728–733PubMedCrossRefGoogle Scholar
  4. Chen W, Nishimura N, Oda H, Yohogoshi H (2003) Effect of taurine on cholesterol degradation and bile acid pool in rats fed a high-cholesterol diet. Taurine 5:Beginning the 21st Century 261–267.Google Scholar
  5. Choi MJ (2009) Effects of taurine supplementation on bone mineral density in overiectomized rats fed calcium deficient diet. Nutr Res Pract 3:108–113PubMedCrossRefGoogle Scholar
  6. Choi MJ, DiMarco NM (2009) The effects of dietary taurine supplementation on bone mineral density in ovariectomized rats. Adv Exp Med Biol 643:341–349PubMedCrossRefGoogle Scholar
  7. Foos TM, Wu JY (2002) The role of taurine in the central nervous system and the modulation of intracellular calcium homeostasis. Neurochem Res 27:21–26PubMedCrossRefGoogle Scholar
  8. Hayes KC, Stuiman JA (1981) Taurine in metabolism. Annu Rev Nutr 1:401–425PubMedCrossRefGoogle Scholar
  9. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163PubMedGoogle Scholar
  10. Ikuyama S, Okajima T, Kato K, Ibayashi H (1988) Effect of taurine on growth hormone and prolactin secretion in rats: possible interaction with opioid peptidergic system. Life Sci 43:807–812PubMedCrossRefGoogle Scholar
  11. Ji H, Zhao G, Luo J, Zhao X, Zhang M (2012) Taurine postponed the replicative senescence of rat bone marrow-derived multipotent stromal cells in vitro. Mol Cell Biochem 366:259–267PubMedCrossRefGoogle Scholar
  12. Koide M, Okahashi N, Tanaka R, Shibasaki K, Yamazaki Y, Kaneko K, Veda N, Ohguchi M, Ishihara Y, Noguchi T et al (1999) Ihibition of experimental bone resorption and osteoclast formation and survival by 2-amino ethane sulphonic acid. Arch Oral Biol 44:711–719PubMedCrossRefGoogle Scholar
  13. Lubec B, Ya-Hua Z, Pertti T, Kitzmuller E, Lubec G (1997) Distribution and disappearance of the ratio labled carbon derived from arginine and taurine in mouse. Life Sci 60:2378–2381CrossRefGoogle Scholar
  14. Mantovani J, DeVivo DC (1979) Effects of taurine on seizures and growth hormone release in epileptic patients. Arch Neurol 36:672–674PubMedCrossRefGoogle Scholar
  15. Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K, Sakono M, Fukuda N (2002) Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci 70:2355–2366PubMedCrossRefGoogle Scholar
  16. McKee JR (1999) Biochemistry: an introduction, 2nd edn. Life Science Publication Co, Orem, UT, pp 219–220Google Scholar
  17. Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD (2004) Skeletal unloading induces resistance to insulin-like growth factor-I(IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res 19(3):436–446PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Food and NutritionKeimyung UniversityDaeguSouth Korea

Personalised recommendations