Advertisement

Taurine 8 pp 347-355 | Cite as

Taurine Enhances the Sexual Response and Mating Ability in Aged Male Rats

  • Jiancheng Yang
  • Shumei Lin
  • Ying Feng
  • Gaofeng Wu
  • Jianmin HuEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 776)

Abstract

It has been demonstrated that taurine is abundant in male reproductive organs, and can be biosynthesized by testis, but the taurine concentration will reduce with aging. The levels of serum LH, T, NOS, and NO were found to be obviously increased by taurine supplementation in aged rats in our previous study. In addition, aging will result in a significant decline in sexual response and function, which may be attributed to the androgen deficiency. Furthermore, NO has been proposed as a crucial mediator of penile erection. That makes us hypothesize that there is potential relationship between taurine decline and erection dysfunction in aged males. So the primary aim of the present study was to investigate the effect of taurine on male sexuality in rats. Taurine was offered in water to male aged (20 months old) rats for 110 days. The effects of taurine on the sexual response, mating ability, levels of serum reproductive hormones, and penile NOS and NO levels were investigated. The results showed that taurine can significantly reduce the EL and ML; obviously increase the ERF, MF, IF, and EJF; stimulate the secretion of GnRH, LH, and T; and elevate penis NOS and NO level in aged rats. The results indicated that taurine can enhance the sexual response and mating ability in aged male rats by increasing the level of testosterone and NO, but the exact mechanism of which needs to be further investigated.

Keywords

Nitric Oxide Luteinizing Hormone Sexual Response Penile Erection Taurine Supplement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

LH

Luteinizing hormone

T

Testosterone

NOS

Nitric oxide synthase

NO

Nitric oxide

Con

Control group

Tau

Taurine group

β-Ala

β-Alanine group

EL

Erection latency

ERF

Erection frequency

ML

Mount latency

MF

Mount frequency

IF

Intromission frequency

EJF

Ejaculation frequency

GnRH

Gonadotropin-releasing hormone

FSH

Follicle-stimulating hormone

E2

Estradiol

LH

Luteinizing hormone

TP

Total protein

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 31001042), the Doctor Initial Foundation of Liaoning Province (Grant No. 20081065), and the Program for Shenyang Agricultural University Excellent Talents.

References

  1. Alvarez JG, Storey BT (1983) Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biol Reprod 29:548–555PubMedCrossRefGoogle Scholar
  2. Andersson KE, Wagner G (1997) Physiology of penile erection. Physiol Rev 75:191–236Google Scholar
  3. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH (1992) Nitric oxide: a physiologic mediator of penile erection. Science 257(5068):401–403PubMedCrossRefGoogle Scholar
  4. Dawson R Jr, Wallace DR (1992) Taurine content in tissues from aged Fisher 344 rats. Age 15:73–81CrossRefGoogle Scholar
  5. Fraser LR (1986) Both taurine and albumin support mouse sperm motility and fertilizing ability in vitro but there is no obligatory requirement for taurine. J Reprod Fertil 77:271–280PubMedCrossRefGoogle Scholar
  6. Holmes RP, Goodman HO, Shihabi ZK, Jarrow JP (1992) The taurine and hypotaurine content of human semen. J Androl 13:289–292PubMedGoogle Scholar
  7. Hu JM, Ikemura R, Chang KT, Suzuki M, Nishihara M, Takahashi M (2000) Expression of cysteine sulfinate decarboxylase mRNA in rat mammary gland. J Vet Med Sci 62(8):829–834PubMedCrossRefGoogle Scholar
  8. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72(1):101–163PubMedGoogle Scholar
  9. Lamberts SWJ, van den Beld AW, van der Lely AJ (1997) The endocrinology of aging. Science 278:419–424PubMedCrossRefGoogle Scholar
  10. Li JH, Ling YQ, Fan JJ, Zhang XP, Cui S (2006) Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice. Histochem Cell Biol 125:607–613PubMedCrossRefGoogle Scholar
  11. Lobo MVT, Alonso FJM, del Rio RM (2000) Immunohistochemical localization of taurine in the male reproductive organs of the rat. J Histochem Cytochem 48:313–320PubMedCrossRefGoogle Scholar
  12. Lugg J, Rafjer J, Gonzales-Cadavit NF (1995) Dihydrotestosterone is the active androgen in the maintenance of nitric-oxide mediated penile erection in the rat. Endocrinology 136:1495–1501PubMedCrossRefGoogle Scholar
  13. Lumley LA, Hull EM (1999) Effects of a D1antagonist and of sexual experience on copulation-induced Fos-like immunoreactivity in the medial preoptic nucleus. Brain Res 829(1–2):55–68PubMedCrossRefGoogle Scholar
  14. Meacham RB, Murray MJ (1994) Reproductive function in the aging male. Urol Clin North Am 21:549–556PubMedGoogle Scholar
  15. Meizel S (1985) Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anat 174(3):285–302PubMedCrossRefGoogle Scholar
  16. Meizel S, Lui CW, Working PK, Mrsny RJ (1980) Taurine and hypotaurine: their effects on motility, capacitation and the acrosome reaction of hamster sperm in vitro and their presence in sperm and reproductive tract fluids of several mammals. Dev Growth Differ 22(3):483–494CrossRefGoogle Scholar
  17. Mills TM, Reilly CM, Lewis RW (1996) Androgens and penile erection: a review. J Androl 17:633–638PubMedGoogle Scholar
  18. Mrsny RJ, Meizel S (1985) Inhibition of hamster sperm Na+, K+-ATPase activity by taurine and hypotaurine. Life Sci 36(3):271–275PubMedCrossRefGoogle Scholar
  19. Mulliqan T, Schmitt B (1993) Testosterone for erectile failure. J Gen Intern Med 8(9):517–521CrossRefGoogle Scholar
  20. Oertel WH, Schmechel DE, Weise VK, Ransom DH, Tappaz ML, Krutzsch HC, Kopin IJ (1981) Comparison of cysteine sulphinic acid decarboxylase isoenzymes and glutamic acid decarboxylase in rat liver and brain. Neuroscience 6:2701–2714PubMedCrossRefGoogle Scholar
  21. Pasantes-Morales H, Lopez-colome AM, Salceda R, Mandel P (1976) Cysteine sulphinate decarboxylase in chick and rat retina during development. J Neurochem 27:1103–1106PubMedCrossRefGoogle Scholar
  22. Reilly CM, Zamorano P, Stopper VS, Mills TM (1997) Androgenic regulation of NO availability in rat penile erection. J Androl 18(2):110–115PubMedGoogle Scholar
  23. Sachs BD, Akasofu K, McEldowney SS (1994) Effects of copulation on apomorphine-induced erection in rats. Pharmacol Biochem Behav 48(2):423–428PubMedCrossRefGoogle Scholar
  24. Schiavi RC, Rehman J (1995) Sexuality and aging. Urol Clin North Am 22:711–726PubMedGoogle Scholar
  25. Swerdloff RS, Wang C (1993) Androgen deficiency and aging in men. West J Med 159:579–585PubMedGoogle Scholar
  26. Tenover JL (1997) Testosterone and the aging male. J Androl 18:103–106PubMedGoogle Scholar
  27. Wallace DR, Dawson JR (1990) Decreased plasma taurine in aged rats. Gerontology 36(1):19–27PubMedCrossRefGoogle Scholar
  28. Yang JC, Wu GF, Feng Y, Lv QF, Lin SM, Hu JM (2010a) Effects of taurine on male reproduction in rats of different ages. J Biomed Sci 17(Suppl 1):1–8, S9Google Scholar
  29. Yang JC,Wu GF, Feng Y, Sun CM, Lin SM, Hu JM (2010b) CSD mRNA expression in rat testis and the effect of taurine on testosterone secretion. Amino Acids 39(1):155–160Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jiancheng Yang
    • 1
  • Shumei Lin
    • 1
  • Ying Feng
    • 1
  • Gaofeng Wu
    • 1
  • Jianmin Hu
    • 1
    Email author
  1. 1.College of Animal Science & Veterinary Medicine, Shenyang Agricultural UniversityShenyangPeople’s Republic of China

Personalised recommendations