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Taurine 8 pp 335–345Cite as

Effect of Dietary Taurine and Arginine Supplementation on Bone Mineral Density in Growing Female Rats

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 776))

Abstract

The purpose of this study was to determine the effect of arginine or ­taurine alone and taurine plus arginine on bone mineral density (BMD) and markers of bone formation and bone resorption in growing female rats. Forty female SD rats (75 ± 5 g) were randomly divided into four groups (control, taurine, arginine, taurine + arginine group) and treatment lasted for 9 weeks. All rats were fed on a diet and deionized water. BMD and bone mineral content (BMC) were measured using PIXImus (GE Lunar Co, Wisconsin, USA) in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined. Bone formation was measured by serum osteocalcin and alkaline phosphatase concentrations, and the bone resorption rate was measured by deoxypyridinoline cross-links. Femur BMD was significantly increased in the group with taurine supplementation and femur BMC/weight was significantly increased in the group with arginine + taurine supplementation. Rats fed an arginine or taurine supplemental diet increased femur BMD or femur BMC, but a taurine + arginine-supplemented diet does not have a better effect than arginine or taurine alone in the spine BMD. The femur BMC, expressed per body weight, was higher in arginine + taurine group than in the taurine or arginine group. The results of this study suggest that taurine + arginine supplementation may be beneficial on femur BMC in growing female rats. Additional work is needed to clarify the interactive effects between the taurine and arginine to determine whether dietary intakes of arginine and taurine affect bone quality in growing rats.

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Abbreviations

ALP:

Alkaline phosphatase

DPD:

Deoxypyridinoline

Arg:

Arginine

Tau:

Taurine

Arg + Tau:

Arginine + taurine

DPD/Cr:

Creatinine excretion

AI:

Adequate intake

BMD:

Bone mineral density

BMC:

Bone mineral content

FER:

Food efficiency ratio

SBMD:

Spine bone mineral density

SBMC:

Spine bone mineral content

FBMD:

Femur bone mineral density

FBMC:

Femur bone mineral content

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Acknowledgements

This research was supported by the Bisa Research Grant of Keimyung University in 2010.

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Authors and Affiliations

  1. Department of Food and Nutrition, Keimyung University, 1000 Sindangdong, Dalseogu, Daegu, 704-701, South Korea

    Mi-Ja Choi

  2. Department of Food and Nutrition, Inha University, Incheon, South Korea

    Kyung Ja Chang

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  1. Mi-Ja Choi
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Correspondence to Mi-Ja Choi .

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Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

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Choi, MJ., Chang, K.J. (2013). Effect of Dietary Taurine and Arginine Supplementation on Bone Mineral Density in Growing Female Rats. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 776. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6093-0_31

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