Taurine 8 pp 321-328 | Cite as

The Role of Taurine on Skeletal Muscle Cell Differentiation

  • Teruo MiyazakiEmail author
  • Akira Honda
  • Tadashi Ikegami
  • Yasushi Matsuzaki
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 776)


Taurine abundantly contained in the skeletal muscle has been considered as one of essential factors for the differentiation and growth of skeletal muscles. The previous studies in the taurine transporter knockout mice showed that deficiency of taurine content in the skeletal muscle caused incomplete muscular developments, morphological abnormalities, and exercise abilities. In fetal and neonatal periods, taurine must be an essential amino acid due to no biosynthesis capacity, and therefore, taurine should be endogenously supplied through placenta and maternal milk. In general cell culture condition, taurine contained in the culture medium is absent or few, and therefore, most of cultured cells are in taurine-deficient condition. In the present study, we confirmed, in cultured mouse differentiable myoblast, taurine treatment significantly enhanced the differentiation to myotube in a dose-dependent manner, while these effects were abrogated by inhibitions of taurine transport and Ca2+ signaling pathway.

The present study suggested that exogenous taurine might play a key role on the mature differentiation/growth of the skeletal muscle during development period through Ca2+ signaling pathway, and therefore, taurine would contribute the muscle recovery after damages.


C2C12 Cell C2C12 Myoblast C2C12 Myotube Taurine Transport Taurine Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Taurine transporter


Growth medium


Differentiation medium


Myosin heavy chain


Myocyte-enriched calcineurin-interacting protein



This work was supported in part by Kakenhi grants (21790633) from the Japan Society for the Promotion of Science.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Teruo Miyazaki
    • 1
    Email author
  • Akira Honda
    • 2
    • 3
  • Tadashi Ikegami
    • 3
  • Yasushi Matsuzaki
    • 3
  1. 1.Joint Research CenterTokyo Medical University Ibaraki Medical CenterAmiJapan
  2. 2.Joint Research CenterTokyo Medical University Ibaraki Medical CenterAmiJapan
  3. 3.Department of Gastroenterology and HepatologyTokyo Medical University Ibaraki Medical CenterAmiJapan

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