Taurine 8 pp 93-103 | Cite as

Effects of Taurine Supplementation Upon Food Intake and Central Insulin Signaling in Malnourished Mice Fed on a High-Fat Diet

  • Rafael L. CamargoEmail author
  • Thiago M. Batista
  • Rosane A. Ribeiro
  • Lício A. Velloso
  • Antônio C. Boschero
  • Everardo M. Carneiro
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 776)


Feeding behavior is a major determinant of body composition, adiposity, and glucose homeostasis. Both obesity and malnutrition are risk factors for the metabolic syndrome and are associated with altered food intake. Here we assessed the effects of taurine (TAU) supplementation upon adiposity, food intake, and central insulin signaling in malnourished mice fed on a high-fat diet (HFD). Weaned male C57BL/6 mice were fed a control (14% protein-C) or a protein-restricted (6% protein-R) diet. After 6 weeks, both groups received or not HFD for 8 weeks (CH and RH). Half of the HFD groups were supplemented with 5% TAU (CHT and RHT). Both HFD groups were overweight and showed increased perigonadal and retroperitoneal fat pads. TAU supplementation attenuated obesity in CHT but not in RHT mice. HFD induced hypercholesterolemia and glucose intolerance, although only CH group presented fasting hyperglycemia. TAU supplementation also improved glucose homeostasis only in CHT mice. Western blot analysis showed a reduction of 55% in CH hypothalamic content of phosphorylated IRS-1 (pIRS-1) at basal condition compared with C. TAU treatment increased 35% Akt phosphorylation levels in CHT without modification in RHT hypothalamus. However, TAU supplementation did not alter hypothalamic pIRS-1 amount. CH and RH mice presented increased calorie intake that was normalized in CHT but not in RHT. In conclusion, mice fed on an HFD developed obesity, hypercholesterolemia, glucose intolerance, and increased calorie intake. TAU promoted increased hypothalamic insulin action only in CH mice which was linked to prevention of overfeeding, obesity, and glucose intolerance. Protein-restriction promoted metabolic damages that were not prevented by TAU supplementation.


Intraperitoneal Glucose Tolerance Test Central Insulin Hypothalamic Content Increase Calorie Intake Malnourished Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Arcuate nuclei


Type 2 diabetes mellitus


Central nervous system




Tumor necrosis factor



This study was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional para o Desenvolvimento Científico e Tecnológico (CNPq), and Instituto Nacional de Ciência e Tecnologia (INCT).


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rafael L. Camargo
    • 1
    Email author
  • Thiago M. Batista
    • 1
  • Rosane A. Ribeiro
    • 2
  • Lício A. Velloso
    • 3
  • Antônio C. Boschero
    • 1
  • Everardo M. Carneiro
    • 1
  1. 1.Departamento de Biologia Funcional e Estrutural, Instituto de BiologiaUniversidade Estadual de CampinasCampinasBrazil
  2. 2.Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM)Universidade Federal do Rio de Janeiro (UFRJ)MacaéBrazil
  3. 3.Departamento de Clínica Médicas, Faculdade de Ciências MédicasUniversidade Estadual de CampinasCampinasBrazil

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