Molecular Pathology of Squamous Carcinomas of the Esophagus

  • Rohinton S. Tarapore
  • Jonathan P. KatzEmail author
Part of the Molecular Pathology Library book series (MPLB, volume 7)


Esophageal squamous cell carcinoma (ESCC) is a form of cancer that has varying incidence rates among different countries, distinct geographic areas, and different ethnic groups. This malignancy has a multifactorial etiology involving environmental, dietary, and genetic factors. Tobacco smoking, excessive alcohol consumption, low intake of fruits and vegetables, and low socioeconomic status are some of the factors that contribute to increased risk of ESCC. Several studies have been undertaken regarding the molecular alterations associated with esophageal carcinogenesis. Despite a better understanding of the risk factors and the molecular and cellular derangements associated with ESCC, the clinical treatment has not changed significantly in recent years, and long-term survival from esophageal cancer remains poor. This chapter provides a conceptual basis for evaluating studies on the risks and the molecular mechanisms underlying esophageal squamous cell carcinogenesis and for devising therapeutic and preventive strategies to reduce the mortality of ESCC.


Esophageal Cancer Esophageal Squamous Cell Carcinoma Human Papilloma Virus Adenomatous Polyposis Coli Cigarette Smoke Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of GastroenterologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of GastroenterologyUniversity of PennsylvaniaPhiladelphiaUSA

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