Targeted Therapies and Molecular Diagnostics of Gastrointestinal Cancers

  • Davendra Sohal
  • Antonia R. Sepulveda
  • Weijing SunEmail author
Part of the Molecular Pathology Library book series (MPLB, volume 7)


Clinical applications of genomic medicine and molecular diagnostics based on testing of tumor tissues are becoming a reality in clinical practice, with significant impact on personalized therapies for cancer patients. Advances in targeted therapies for cancers of the gastrointestinal tract have recently emerged and are rapidly moving targets. In this chapter, we review the targeted therapies that are currently standard of practice in colorectal and gastric cancers, requiring specific molecular testing for selection of candidate patients for therapy.


Gastric Cancer Epidermal Growth Factor Receptor Lynch Syndrome KRAS Mutation BRAF Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Davendra Sohal
    • 1
  • Antonia R. Sepulveda
    • 2
  • Weijing Sun
    • 3
    Email author
  1. 1.Solid Tumor OncologyTaussig Cancer Institute, Cleveland ClinicClevelandUSA
  2. 2.Department of Pathology & Cell BiologyColumbia UniversityNew YorkUSA
  3. 3.Department of Medicine, Hematology-OncologyUniversity of Pittsburgh School of Medicine, UPMC Cancer PavilionPittsburghUSA

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