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Serological Markers of Digestive Tract Cancers

  • Jorge L. SepulvedaEmail author
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 7)

Abstract

Serum protein biomarkers offer the potential to diagnose and monitor GI tumors with simple, quantitative, easily automated, and inexpensive assays. Unfortunately the diagnostic accuracy of current and most prospective markers is insufficient to recommend their use in isolation for tumor detection, especially in the general population. In contrast, the role of serum protein markers in monitoring the response to treatment is well accepted, particularly for the Carcinoembryonic Antigen (CEA) in colorectal cancer. Other glycoprotein markers, such as CA19-9 and CA242, have shown some value, particularly in combination with CEA, in detecting and monitoring advanced GI cancers. The list of newer, potential markers is large and likely to expand at an increasing rate, especially in consequence of large-scale “omic” approaches. While comprehensive proteomic approaches are unlikely to be used in the near future, combinatorial panels of selected markers offering increased sensitivity and specificity are expected to replace single biomarkers in the evaluation of patients with GI tumors.

Keywords

Cytosine Deaminase Medullary Thyroid Carcinomas115 Thermal Lens Microscopy Tumor Marker Measurement Serum Protein Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pathology & Cell BiologyColumbia UniversityNew YorkUSA

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