Neuroendocrine Tumors

  • Joseph R. PisegnaEmail author
Part of the Molecular Pathology Library book series (MPLB, volume 7)


Neuroendocrine tumors of the digestive tract share many pathologic and molecular features as well as management approaches. This chapter will focus on neuroendocrine tumors of the pancreas.

Neuroendocrine tumors (NETs) of the pancreas, although previously thought to be relatively rare, are becoming increasingly recognized in clinical practice and continue to pose a significant challenge to both clinicians and pathologists. The diagnosis is facilitated when there is a high index of suspicion based on clinical symptoms and confirmation can be made by biopsy or cytological sampling and pathological diagnosis. The utility of biochemical testing is a useful adjunct not only for the diagnosis but also for the prognosis and therapeutic follow-up. Over the past decade, there has been significant progress made in the identification of the biology and treatment of NETs. In this chapter, we will review the epidemiology, pathology, and clinical syndromes for the pancreatic neuroendocrine tumors, formerly referred to as pancreatic or islet cell tumors. The latter part of this chapter will focus on the more recent advances in localization modalities and treatment options, especially given the newly FDA-approved chemotherapy for their treatment.


Neuroendocrine Tumor Gastric Acid Secretion Vasoactive Intestinal Polypeptide Pancreatic Polypeptide Serum Gastrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Gastroenterology and HepatologyVA Greater Los Angeles Healthcare SystemLos AngelesUSA

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