Molecular Biology and Pathology of Gastrointestinal Stromal Tumors

  • Paul J. ZhangEmail author
Part of the Molecular Pathology Library book series (MPLB, volume 7)


Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal (GI) tract with characteristic histologic and molecular features. These tumors are KIT or PDFGRA mutation-driven mesenchymal tumors of the gastrointestinal tract originating from the interstitial cells of Cajal (ICC) or their precursors, and they generally express CKIT protein. GISTs are the most common malignant mesenchymal tumors of the gastrointestinal (GI) tract and about 5,000 new cases are diagnosed each year in the United States.


Imatinib Treatment Secondary Mutation Gastric GISTs PDGFRA Mutation Juxtamembrane Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pathology and Lab MedicineUniversity of Pennsylvania Medical CenterPhiladelphiaUSA

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