Abstract
Current recommendations for the treatment of patients with irreversible airflow obstruction involve the stepwise addition of bronchodilator and anti-inflammatory medications to improve airflow through narrowed and obstructed bronchioles. While this approach effectively treats individuals with chronic obstructive pulmonary disease (COPD) caused by reactive airway disease and mucous hypersecretion, including those with chronic bronchitis and asthma, it is less effective in individuals whose disease is primarily due to pulmonary emphysema. In this latter group, the fundamental problem is tissue destruction caused by chronic inflammation associated with prolonged exposure to toxic inhalants. This results in the loss of elastic recoil, progressive hyperinflation, and airflow limitation that is minimally responsive to bronchodilator and anti-inflammatory medications.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gold PM. The 2007 GOLD guidelines: a comprehensive care framework. Respir Care. 2009;54:1040–9.
Fessler HE, Scharf SM, Ingenito EP, et al. Physiologic basis for improved pulmonary function after lung volume reduction. Proc Am Thorac Soc. 2008;5:416–20.
Cooper JD, Patterson GA, Sundaresan RS, et al. Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema. J Thorac Cardiovasc Surg. 1996;112:1319–29. discussion 1329–30.
Yusen RD, Lefrak SS, Gierada DS, et al. A prospective evaluation of lung volume reduction surgery in 200 consecutive patients. Chest. 2003;123:1026–37.
Yusen RD, Trulock EP, Pohl MS, et al. Results of lung volume reduction surgery in patients with emphysema. The Washington University Emphysema Surgery Group. Semin Thorac Cardiovasc Surg. 1996;8:99–109.
Gelb AF, Brenner M, McKenna Jr RJ, et al. Serial lung function and elastic recoil 2 years after lung volume reduction surgery for emphysema. Chest. 1998;113:1497–506.
Gelb AF, McKenna Jr RJ, Brenner M. Expanding knowledge of lung volume reduction. Chest. 2001;119: 1300–2.
Criner GJ, Sternberg AL. National Emphysema Treatment Trial: the state-of-the-art of the evaluation and treatment of emphysema. Introduction. Proc Am Thorac Soc. 2008;5:380.
Naunheim KS, Wood DE, Krasna MJ, et al. Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment Trial. J Thorac Cardiovasc Surg. 2006;131:43–53.
Ramsey SD, Berry K, Etzioni R, et al. Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N Engl J Med. 2003;348: 2092–102.
Ingenito EP, Loring SH, Moy ML, et al. Physiological characterization of variability in response to lung volume reduction surgery. J Appl Physiol. 2003;94:20–30.
Ingenito EP, Tsai LW. Evolving endoscopic approaches for treatment of emphysema. Semin Thorac Cardiovasc Surg. 2007;19:181–9.
Ingenito EP, Wood DE, Utz JP. Bronchoscopic lung volume reduction in severe emphysema. Proc Am Thorac Soc. 2008;5:454–60.
Herth FJ, Eberhardt R, Ingenito EP, et al. Assessment of a novel lung sealant for performing endoscopic volume reduction therapy in patients with advanced emphysema. Expert Rev Med Devices. 2011;8:307–12.
Giri A, Bhowmick M, Pal S, et al. Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium. Int J Biol Macromol. 2011;49:885–93.
Liu J, Zhang L, Yang Z, et al. Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro. Int J Nanomedicine. 2011;6:2143–53.
Saito T, Tabata Y. Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy. Acta Biomater. 2012;8:646–52.
Aviles MO, Shea LD. Hydrogels to modulate lentivirus delivery in vivo from microporous tissue engineering scaffolds. Drug Deliv Transl Res. 2011;1: 91–101.
Dumville JC, O’Meara S, Deshpande S, et al. Hydrogel dressings for healing diabetic foot ulcers. Cochrane Database Syst Rev 2011:CD009101
Helary C, Zarka M, Giraud-Guille MM. Fibroblasts within concentrated collagen hydrogels favour chronic skin wound healing. J Tissue Eng Regen Med. 2012;6: 225–37.
Ingenito EP, Berger RL, Henderson AC, et al. Bronchoscopic lung volume reduction using tissue engineering principles. Am J Respir Crit Care Med. 2003;167:771–8.
Smokovitis A, Astrup T. A histochemical study of fibrinolytic activity and inhibition of plasmin in the lungs of some animal species. Haemostasis. 1977;6: 318–28.
Ingenito EP, Reilly JJ, Mentzer SJ, et al. Bronchoscopic volume reduction: a safe and effective alternative to surgical therapy for emphysema. Am J Respir Crit Care Med. 2001;164:295–301.
Reilly J, Washko G, Pinto-Plata V, et al. Biological lung volume reduction: a new bronchoscopic therapy for advanced emphysema. Chest. 2007;131:1108–13.
Criner GJ, Pinto-Plata V, Strange C, et al. Biologic lung volume reduction in advanced upper lobe emphysema: phase 2 results. Am J Respir Crit Care Med. 2009;179:791–8.
Refaely Y, Dransfield M, Kramer MR, et al. Biologic lung volume reduction therapy for advanced homogeneous emphysema. Eur Respir J. 2010;36:20–7.
Herth FJ, Gompelmann D, Stanzel F, et al. Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal(R)). Respiration. 2011;82: 36–45.
Washko GR, Fan VS, Ramsey SD, et al. The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med. 2008;177:164–9.
Criner GJ, Sternberg AL. National Emphysema Treatment Trial: the major outcomes of lung volume reduction surgery in severe emphysema. Proc Am Thorac Soc. 2008;5:393–405.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ingenito, E.P. (2013). Endoscopic Lung Volume Reduction for Treatment of Advanced Emphysema Using Injectable Hydrogels. In: DÃaz-Jimenez, J., Rodriguez, A. (eds) Interventions in Pulmonary Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6009-1_28
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6009-1_28
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6008-4
Online ISBN: 978-1-4614-6009-1
eBook Packages: MedicineMedicine (R0)