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Photodynamic Therapy for Early and Advanced Lung Cancer

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Interventions in Pulmonary Medicine

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Abstract

Photodynamic therapy (PDT) is a minimally invasive therapy that can be applied in early and advanced lung cancer. It is based on the intravenous administration of a photosensitizing (PS) substance that accumulates selectively in tumor tissues, and when stimulated with a light of a given wavelength, it generates reactive singlet oxygen that mediates cellular cytotoxicity and ultimately results in cellular death. It is a minimally invasive treatment, easy to apply and well tolerated. Its main adverse effect is photosensitivity.

Current indications in lung cancer are limited to treatment of early “in situ” endobronchial carcinoma, roentgenographically occult, or synchronous primary carcinomas.

In advanced disease, it can be applied alone or in combination with other modalities to palliate tumor obstruction of the airway. Also, it can be indicated to increase operability or to limit the extent of lung resection in surgical candidates.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Interventional Pulmonology Training Center MD Anderson Cancer Center Houston University of Texas, 1515 Holcombe Blv., Houston, TX, 77030, USA

    Jose Pablo Díaz-Jimenez M.D., Ph.D., F.C.C.P. (Director)

  2. Pulmonology-Respiratory Endoscopy Unit, Hospital Universitari de Bellvitge, Catalonia, Spain

    Rachid Tazi Mezalek MD

Authors
  1. Jose Pablo Díaz-Jimenez M.D., Ph.D., F.C.C.P.
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  2. Rachid Tazi Mezalek MD
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Corresponding author

Correspondence to Jose Pablo Díaz-Jimenez M.D., Ph.D., F.C.C.P. .

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Editors and Affiliations

  1. MD Anderson Cancer Center, Houston, TX, Department of Pulmonary Medicine, Bellvitge University Hospital, Barcelona, 08907, Spain

    Jose Pablo Díaz-Jimenez

  2. Clinica Y Maternidad Colon, Pulmonary Department, Mar Del Plata, Buenos Aires, 7600, Argentina

    Alicia N. Rodriguez

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Díaz-Jimenez, J.P., Mezalek, R.T. (2013). Photodynamic Therapy for Early and Advanced Lung Cancer. In: Díaz-Jimenez, J., Rodriguez, A. (eds) Interventions in Pulmonary Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6009-1_10

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  • DOI: https://doi.org/10.1007/978-1-4614-6009-1_10

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