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Descriptive, Environmental and Genetic Epidemiology of Nasopharyngeal Carcinoma

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Nasopharyngeal Carcinoma

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 778))

Abstract

Nasopharyngeal carcinoma (NPC) is a rare tumor in most countries but is more prevalent in Southeast Asia, North Africa and Artic regions. Multiple factors participate in the etiology of NPC including Epstein-Barr virus (EBV) activation, genetic susceptibility and exposure to environmental carcinogens. Specifically, risk factors consistently associated with NPC in endemic areas include early childhood salted fish consumption, preserved foods consumption, lack of fresh fruit or leafy vegetables intake, prior chronic respiratory tract conditions, and exposure to cooking fumes. EBV may act as a tumor promoting agent rather than an initiator in the progress of NPC carcinogenesis. Genetic susceptibility to NPC is largely mediated by the human leukocyte antigen (HLA) class I genes region, although it is not clear whether HLA is causative.

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Authors and Affiliations

  1. Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA

    Bing-Jian Feng

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  1. CNRS and Institut de Cancérologie Gustave Roussy, Université Paris-Sud 11, UMR 8126, Villejuif, France

    Pierre Busson MD, PhD

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Feng, BJ. (2013). Descriptive, Environmental and Genetic Epidemiology of Nasopharyngeal Carcinoma. In: Busson, P. (eds) Nasopharyngeal Carcinoma. Advances in Experimental Medicine and Biology, vol 778. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5947-7_3

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